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5L4G

The human 26S proteasome at 3.9 A

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, O
(N, A)
Proteasome subunit alpha type-6polymer24627432.52UniProt (P60900)
Pfam (PF00227)
Pfam (PF10584)
Homo sapiens (Human)27 kDa prosomal protein,p27K,Macropain iota chain,Multicatalytic endopeptidase complex iota chain,Proteasome iota chain
2B, P
(O, B)
Proteasome subunit alpha type-2polymer23425927.52UniProt (P25787)
Pfam (PF10584)
Pfam (PF00227)
Homo sapiens (Human)Macropain subunit C3,Multicatalytic endopeptidase complex subunit C3,Proteasome component C3
3C, Q
(P, C)
Proteasome subunit alpha type-4polymer26129525.82UniProt (P25789)
Pfam (PF10584)
Pfam (PF00227)
Homo sapiens (Human)Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit L
4D, R
(Q, D)
Proteasome subunit alpha type-7polymer24827929.92UniProt (O14818)
Pfam (PF10584)
Pfam (PF00227)
Homo sapiens (Human)Proteasome subunit RC6-1,Proteasome subunit XAPC7
5E, S
(R, E)
Proteasome subunit alpha type-5polymer24126436.02UniProt (P28066)
Pfam (PF10584)
Pfam (PF00227)
Homo sapiens (Human)Macropain zeta chain,Multicatalytic endopeptidase complex zeta chain,Proteasome zeta chain
6F, T
(S, F)
Proteasome subunit alpha type-1polymer26329595.62UniProt (P25786)
Pfam (PF10584)
Pfam (PF00227)
Homo sapiens (Human)30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain
7G, U
(T, G)
Proteasome subunit alpha type-3polymer25528469.32UniProt (P25788)
Pfam (PF10584)
Pfam (PF00227)
Homo sapiens (Human)Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8
8H, V
(U, 1)
Proteasome subunit beta type-1polymer24126522.42UniProt (P20618)
Pfam (PF00227)
Homo sapiens (Human)Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain
9I, W
(V, 2)
Proteasome subunit beta type-2polymer20122864.32UniProt (P49721)
Pfam (PF00227)
Homo sapiens (Human)Macropain subunit C7-I,Multicatalytic endopeptidase complex subunit C7-I,Proteasome component C7-I
10J, X
(W, 3)
Proteasome subunit beta type-3polymer20522972.92UniProt (P49720)
Pfam (PF00227)
Homo sapiens (Human)Proteasome chain 13,Proteasome component C10-II,Proteasome theta chain
11K, Y
(X, 4)
Proteasome subunit beta type-4polymer26429231.22UniProt (P28070)
Pfam (PF00227)
Homo sapiens (Human)26 kDa prosomal protein,PROS-26,Macropain beta chain,Multicatalytic endopeptidase complex beta chain,Proteasome beta chain,Proteasome chain 3,HsN3
12L, Z
(Y, 5)
Proteasome subunit beta type-5polymer26328510.22UniProt (P28074)
Pfam (PF00227)
Homo sapiens (Human)Macropain epsilon chain,Multicatalytic endopeptidase complex epsilon chain,Proteasome chain 6,Proteasome epsilon chain,Proteasome subunit MB1,Proteasome subunit X
13AA, M
(Z, 6)
Proteasome subunit beta type-6polymer23925377.72UniProt (P28072)
Pfam (PF00227)
Homo sapiens (Human)Macropain delta chain,Multicatalytic endopeptidase complex delta chain,Proteasome delta chain,Proteasome subunit Y
14BA, N
(8, 7)
Proteasome subunit beta type-7polymer27730000.42UniProt (Q99436)
Pfam (PF00227)
Pfam (PF12465)
Homo sapiens (Human)Macropain chain Z,Multicatalytic endopeptidase complex chain Z,Proteasome subunit Z
15CA
(H)
26S protease regulatory subunit 7polymer43348700.81UniProt (P35998)
Pfam (PF21236)
Pfam (PF00004)
Pfam (PF17862)
Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT1,Proteasome 26S subunit ATPase 2,Protein MSS1
16DA
(I)
26S protease regulatory subunit 4polymer44049260.51UniProt (P62191)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
Homo sapiens (Human)P26s4,26S proteasome AAA-ATPase subunit RPT2,Proteasome 26S subunit ATPase 1
17EA
(K)
26S protease regulatory subunit 6Bpolymer41847426.11UniProt (P43686)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT3,MB67-interacting protein,MIP224,Proteasome 26S subunit ATPase 4,Tat-binding protein 7,TBP-7
18FA
(L)
26S protease regulatory subunit 10Bpolymer38944241.01UniProt (P62333)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT4,Proteasome 26S subunit ATPase 6,Proteasome subunit p42
19GA
(M)
26S protease regulatory subunit 6Apolymer43949266.51UniProt (P17980)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT5,Proteasome 26S subunit ATPase 3,Proteasome subunit P50,Tat-binding protein 1,TBP-1
20HA
(J)
26S protease regulatory subunit 8polymer40645694.01UniProt (P62195)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT6,Proteasome 26S subunit ATPase 5,Proteasome subunit p45,Thyroid hormone receptor-interacting protein 1,TRIP1,p45/SUG
21IA, KA, MA, OA, QA
(H, I, K, L, M)
ADENOSINE-5'-TRIPHOSPHATEnon-polymer507.25Chemie (ATP)
22JA, LA, NA, PA, RA
(H, I, K, L, M)
MAGNESIUM IONnon-polymer24.35Chemie (MG)
23SA
(J)
ADENOSINE-5'-DIPHOSPHATEnon-polymer427.21Chemie (ADP)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains34
Total formula weight1046180.3
Non-Polymers*Number of molecules11
Total formula weight3084.6
All*Total formula weight1049264.9
*Water molecules are not included.

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PDB entries from 2025-05-21

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