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5L4G

The human 26S proteasome at 3.9 A

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1N, AProteasome subunit alpha type-6polymer24627432.52UniProt (P60900)
Pfam (PF00227)
Pfam (PF10584)
In PDB
Homo sapiens (Human)27 kDa prosomal protein,p27K,Macropain iota chain,Multicatalytic endopeptidase complex iota chain,Proteasome iota chain
2O, BProteasome subunit alpha type-2polymer23425927.52UniProt (P25787)
Pfam (PF10584)
Pfam (PF00227)
In PDB
Homo sapiens (Human)Macropain subunit C3,Multicatalytic endopeptidase complex subunit C3,Proteasome component C3
3P, CProteasome subunit alpha type-4polymer26129525.82UniProt (P25789)
Pfam (PF10584)
Pfam (PF00227)
In PDB
Homo sapiens (Human)Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit L
4Q, DProteasome subunit alpha type-7polymer24827929.92UniProt (O14818)
Pfam (PF10584)
Pfam (PF00227)
In PDB
Homo sapiens (Human)Proteasome subunit RC6-1,Proteasome subunit XAPC7
5R, EProteasome subunit alpha type-5polymer24126436.02UniProt (P28066)
Pfam (PF10584)
Pfam (PF00227)
In PDB
Homo sapiens (Human)Macropain zeta chain,Multicatalytic endopeptidase complex zeta chain,Proteasome zeta chain
6S, FProteasome subunit alpha type-1polymer26329595.62UniProt (P25786)
Pfam (PF10584)
Pfam (PF00227)
In PDB
Homo sapiens (Human)30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain
7T, GProteasome subunit alpha type-3polymer25528469.32UniProt (P25788)
Pfam (PF10584)
Pfam (PF00227)
In PDB
Homo sapiens (Human)Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8
8U, 1Proteasome subunit beta type-1polymer24126522.42UniProt (P20618)
Pfam (PF00227)
In PDB
Homo sapiens (Human)Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain
9V, 2Proteasome subunit beta type-2polymer20122864.32UniProt (P49721)
Pfam (PF00227)
In PDB
Homo sapiens (Human)Macropain subunit C7-I,Multicatalytic endopeptidase complex subunit C7-I,Proteasome component C7-I
10W, 3Proteasome subunit beta type-3polymer20522972.92UniProt (P49720)
Pfam (PF00227)
In PDB
Homo sapiens (Human)Proteasome chain 13,Proteasome component C10-II,Proteasome theta chain
11X, 4Proteasome subunit beta type-4polymer26429231.22UniProt (P28070)
Pfam (PF00227)
In PDB
Homo sapiens (Human)26 kDa prosomal protein,PROS-26,Macropain beta chain,Multicatalytic endopeptidase complex beta chain,Proteasome beta chain,Proteasome chain 3,HsN3
12Y, 5Proteasome subunit beta type-5polymer26328510.22UniProt (P28074)
Pfam (PF00227)
In PDB
Homo sapiens (Human)Macropain epsilon chain,Multicatalytic endopeptidase complex epsilon chain,Proteasome chain 6,Proteasome epsilon chain,Proteasome subunit MB1,Proteasome subunit X
13Z, 6Proteasome subunit beta type-6polymer23925377.72UniProt (P28072)
Pfam (PF00227)
In PDB
Homo sapiens (Human)Macropain delta chain,Multicatalytic endopeptidase complex delta chain,Proteasome delta chain,Proteasome subunit Y
148, 7Proteasome subunit beta type-7polymer27730000.42UniProt (Q99436)
Pfam (PF00227)
Pfam (PF12465)
In PDB
Homo sapiens (Human)Macropain chain Z,Multicatalytic endopeptidase complex chain Z,Proteasome subunit Z
15H26S protease regulatory subunit 7polymer43348700.81UniProt (P35998)
Pfam (PF21236)
Pfam (PF00004)
Pfam (PF17862)
In PDB
Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT1,Proteasome 26S subunit ATPase 2,Protein MSS1
16I26S protease regulatory subunit 4polymer44049260.51UniProt (P62191)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
In PDB
Homo sapiens (Human)P26s4,26S proteasome AAA-ATPase subunit RPT2,Proteasome 26S subunit ATPase 1
17K26S protease regulatory subunit 6Bpolymer41847426.11UniProt (P43686)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
In PDB
Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT3,MB67-interacting protein,MIP224,Proteasome 26S subunit ATPase 4,Tat-binding protein 7,TBP-7
18L26S protease regulatory subunit 10Bpolymer38944241.01UniProt (P62333)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
In PDB
Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT4,Proteasome 26S subunit ATPase 6,Proteasome subunit p42
19M26S protease regulatory subunit 6Apolymer43949266.51UniProt (P17980)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
In PDB
Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT5,Proteasome 26S subunit ATPase 3,Proteasome subunit P50,Tat-binding protein 1,TBP-1
20J26S protease regulatory subunit 8polymer40645694.01UniProt (P62195)
Pfam (PF16450)
Pfam (PF00004)
Pfam (PF17862)
In PDB
Homo sapiens (Human)26S proteasome AAA-ATPase subunit RPT6,Proteasome 26S subunit ATPase 5,Proteasome subunit p45,Thyroid hormone receptor-interacting protein 1,TRIP1,p45/SUG
21H, I, K, L, MADENOSINE-5'-TRIPHOSPHATEnon-polymer507.25Chemie (ATP)
22H, I, K, L, MMAGNESIUM IONnon-polymer24.35Chemie (MG)
23JADENOSINE-5'-DIPHOSPHATEnon-polymer427.21Chemie (ADP)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains34
Total formula weight1046180.3
Non-Polymers*Number of molecules11
Total formula weight3084.6
All*Total formula weight1049264.9
*Water molecules are not included.

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PDB entries from 2024-04-17

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