5L4G

The human 26S proteasome at 3.9 A

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000502	cellular_component	proteasome complex
1	0005515	molecular_function	protein binding
1	0005576	cellular_component	extracellular region
1	0005634	cellular_component	nucleus
1	0005654	cellular_component	nucleoplasm
1	0005737	cellular_component	cytoplasm
1	0005829	cellular_component	cytosol
1	0005839	cellular_component	proteasome core complex
1	0019774	cellular_component	proteasome core complex, beta-subunit complex
1	0034774	cellular_component	secretory granule lumen
1	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
1	0051603	biological_process	proteolysis involved in protein catabolic process
1	0070062	cellular_component	extracellular exosome
1	1904813	cellular_component	ficolin-1-rich granule lumen
2	0000502	cellular_component	proteasome complex
2	0005515	molecular_function	protein binding
2	0005634	cellular_component	nucleus
2	0005654	cellular_component	nucleoplasm
2	0005737	cellular_component	cytoplasm
2	0005829	cellular_component	cytosol
2	0005839	cellular_component	proteasome core complex
2	0010243	biological_process	response to organonitrogen compound
2	0010498	biological_process	proteasomal protein catabolic process
2	0014070	biological_process	response to organic cyclic compound
2	0016020	cellular_component	membrane
2	0019774	cellular_component	proteasome core complex, beta-subunit complex
2	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
2	0051603	biological_process	proteolysis involved in protein catabolic process
2	0070062	cellular_component	extracellular exosome
3	0000502	cellular_component	proteasome complex
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005654	cellular_component	nucleoplasm
3	0005737	cellular_component	cytoplasm
3	0005829	cellular_component	cytosol
3	0005839	cellular_component	proteasome core complex
3	0019774	cellular_component	proteasome core complex, beta-subunit complex
3	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
3	0051603	biological_process	proteolysis involved in protein catabolic process
3	0070062	cellular_component	extracellular exosome
4	0000502	cellular_component	proteasome complex
4	0001530	molecular_function	lipopolysaccharide binding
4	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005654	cellular_component	nucleoplasm
4	0005737	cellular_component	cytoplasm
4	0005739	cellular_component	mitochondrion
4	0005829	cellular_component	cytosol
4	0005839	cellular_component	proteasome core complex
4	0019774	cellular_component	proteasome core complex, beta-subunit complex
4	0036064	cellular_component	ciliary basal body
4	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
4	0051603	biological_process	proteolysis involved in protein catabolic process
4	0070062	cellular_component	extracellular exosome
5	0000502	cellular_component	proteasome complex
5	0004175	molecular_function	endopeptidase activity
5	0004298	molecular_function	threonine-type endopeptidase activity
5	0005515	molecular_function	protein binding
5	0005634	cellular_component	nucleus
5	0005654	cellular_component	nucleoplasm
5	0005737	cellular_component	cytoplasm
5	0005813	cellular_component	centrosome
5	0005829	cellular_component	cytosol
5	0005839	cellular_component	proteasome core complex
5	0006508	biological_process	proteolysis
5	0006979	biological_process	response to oxidative stress
5	0008233	molecular_function	peptidase activity
5	0016787	molecular_function	hydrolase activity
5	0019774	cellular_component	proteasome core complex, beta-subunit complex
5	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
5	0051603	biological_process	proteolysis involved in protein catabolic process
5	0070062	cellular_component	extracellular exosome
6	0000502	cellular_component	proteasome complex
6	0004175	molecular_function	endopeptidase activity
6	0004298	molecular_function	threonine-type endopeptidase activity
6	0005515	molecular_function	protein binding
6	0005634	cellular_component	nucleus
6	0005654	cellular_component	nucleoplasm
6	0005737	cellular_component	cytoplasm
6	0005739	cellular_component	mitochondrion
6	0005829	cellular_component	cytosol
6	0005839	cellular_component	proteasome core complex
6	0006508	biological_process	proteolysis
6	0008233	molecular_function	peptidase activity
6	0016787	molecular_function	hydrolase activity
6	0019774	cellular_component	proteasome core complex, beta-subunit complex
6	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
6	0045296	molecular_function	cadherin binding
6	0051603	biological_process	proteolysis involved in protein catabolic process
6	0070062	cellular_component	extracellular exosome
7	0000502	cellular_component	proteasome complex
7	0004175	molecular_function	endopeptidase activity
7	0004298	molecular_function	threonine-type endopeptidase activity
7	0005515	molecular_function	protein binding
7	0005576	cellular_component	extracellular region
7	0005634	cellular_component	nucleus
7	0005654	cellular_component	nucleoplasm
7	0005737	cellular_component	cytoplasm
7	0005829	cellular_component	cytosol
7	0005839	cellular_component	proteasome core complex
7	0006508	biological_process	proteolysis
7	0008233	molecular_function	peptidase activity
7	0016604	cellular_component	nuclear body
7	0016787	molecular_function	hydrolase activity
7	0019774	cellular_component	proteasome core complex, beta-subunit complex
7	0034774	cellular_component	secretory granule lumen
7	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
7	0051603	biological_process	proteolysis involved in protein catabolic process
7	1904813	cellular_component	ficolin-1-rich granule lumen
8	0000502	cellular_component	proteasome complex
8	0004175	molecular_function	endopeptidase activity
8	0004298	molecular_function	threonine-type endopeptidase activity
8	0005515	molecular_function	protein binding
8	0005576	cellular_component	extracellular region
8	0005634	cellular_component	nucleus
8	0005654	cellular_component	nucleoplasm
8	0005737	cellular_component	cytoplasm
8	0005829	cellular_component	cytosol
8	0005839	cellular_component	proteasome core complex
8	0006508	biological_process	proteolysis
8	0008233	molecular_function	peptidase activity
8	0016604	cellular_component	nuclear body
8	0016787	molecular_function	hydrolase activity
8	0019774	cellular_component	proteasome core complex, beta-subunit complex
8	0034774	cellular_component	secretory granule lumen
8	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
8	0051603	biological_process	proteolysis involved in protein catabolic process
8	1904813	cellular_component	ficolin-1-rich granule lumen
A	0000502	cellular_component	proteasome complex
A	0000932	cellular_component	P-body
A	0003723	molecular_function	RNA binding
A	0004175	molecular_function	endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0005840	cellular_component	ribosome
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0010498	biological_process	proteasomal protein catabolic process
A	0016363	cellular_component	nuclear matrix
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0030016	cellular_component	myofibril
A	0030017	cellular_component	sarcomere
A	0035639	molecular_function	purine ribonucleoside triphosphate binding
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0050727	biological_process	regulation of inflammatory response
A	0051059	molecular_function	NF-kappaB binding
A	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0070062	cellular_component	extracellular exosome
B	0000502	cellular_component	proteasome complex
B	0000932	cellular_component	P-body
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0009615	biological_process	response to virus
B	0010498	biological_process	proteasomal protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0034774	cellular_component	secretory granule lumen
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0070062	cellular_component	extracellular exosome
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0000502	cellular_component	proteasome complex
C	0000932	cellular_component	P-body
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0010498	biological_process	proteasomal protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0070062	cellular_component	extracellular exosome
D	0000502	cellular_component	proteasome complex
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0010498	biological_process	proteasomal protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0042802	molecular_function	identical protein binding
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0070062	cellular_component	extracellular exosome
D	0098794	cellular_component	postsynapse
E	0000502	cellular_component	proteasome complex
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0010498	biological_process	proteasomal protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0034774	cellular_component	secretory granule lumen
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
E	0070062	cellular_component	extracellular exosome
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0000502	cellular_component	proteasome complex
F	0001530	molecular_function	lipopolysaccharide binding
F	0002376	biological_process	immune system process
F	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005829	cellular_component	cytosol
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0010498	biological_process	proteasomal protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	0070062	cellular_component	extracellular exosome
G	0000502	cellular_component	proteasome complex
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0010498	biological_process	proteasomal protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0045202	cellular_component	synapse
G	0051603	biological_process	proteolysis involved in protein catabolic process
G	0052548	biological_process	regulation of endopeptidase activity
G	0070062	cellular_component	extracellular exosome
H	0000166	molecular_function	nucleotide binding
H	0000502	cellular_component	proteasome complex
H	0000932	cellular_component	P-body
H	0001649	biological_process	osteoblast differentiation
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0008540	cellular_component	proteasome regulatory particle, base subcomplex
H	0016020	cellular_component	membrane
H	0016887	molecular_function	ATP hydrolysis activity
H	0022624	cellular_component	proteasome accessory complex
H	0034774	cellular_component	secretory granule lumen
H	0036402	molecular_function	proteasome-activating activity
H	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	1901800	biological_process	positive regulation of proteasomal protein catabolic process
H	1904813	cellular_component	ficolin-1-rich granule lumen
I	0000166	molecular_function	nucleotide binding
I	0000502	cellular_component	proteasome complex
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005838	cellular_component	proteasome regulatory particle
I	0008540	cellular_component	proteasome regulatory particle, base subcomplex
I	0016020	cellular_component	membrane
I	0016887	molecular_function	ATP hydrolysis activity
I	0022624	cellular_component	proteasome accessory complex
I	0036402	molecular_function	proteasome-activating activity
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	1901800	biological_process	positive regulation of proteasomal protein catabolic process
J	0000166	molecular_function	nucleotide binding
J	0000502	cellular_component	proteasome complex
J	0005102	molecular_function	signaling receptor binding
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005838	cellular_component	proteasome regulatory particle
J	0006357	biological_process	regulation of transcription by RNA polymerase II
J	0008134	molecular_function	transcription factor binding
J	0008540	cellular_component	proteasome regulatory particle, base subcomplex
J	0016020	cellular_component	membrane
J	0016887	molecular_function	ATP hydrolysis activity
J	0022624	cellular_component	proteasome accessory complex
J	0031410	cellular_component	cytoplasmic vesicle
J	0031531	molecular_function	thyrotropin-releasing hormone receptor binding
J	0036402	molecular_function	proteasome-activating activity
J	0043069	biological_process	negative regulation of programmed cell death
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0045892	biological_process	negative regulation of DNA-templated transcription
J	0045893	biological_process	positive regulation of DNA-templated transcription
J	0070062	cellular_component	extracellular exosome
J	0072562	cellular_component	blood microparticle
J	0140296	molecular_function	general transcription initiation factor binding
J	0140297	molecular_function	DNA-binding transcription factor binding
J	1901800	biological_process	positive regulation of proteasomal protein catabolic process
K	0000166	molecular_function	nucleotide binding
K	0000502	cellular_component	proteasome complex
K	0001824	biological_process	blastocyst development
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0006508	biological_process	proteolysis
K	0008540	cellular_component	proteasome regulatory particle, base subcomplex
K	0016020	cellular_component	membrane
K	0016234	cellular_component	inclusion body
K	0016887	molecular_function	ATP hydrolysis activity
K	0022624	cellular_component	proteasome accessory complex
K	0031597	cellular_component	cytosolic proteasome complex
K	0036402	molecular_function	proteasome-activating activity
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0045202	cellular_component	synapse
K	1901800	biological_process	positive regulation of proteasomal protein catabolic process
L	0000166	molecular_function	nucleotide binding
L	0000502	cellular_component	proteasome complex
L	0005515	molecular_function	protein binding
L	0005524	molecular_function	ATP binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0005829	cellular_component	cytosol
L	0008540	cellular_component	proteasome regulatory particle, base subcomplex
L	0016020	cellular_component	membrane
L	0016234	cellular_component	inclusion body
L	0016887	molecular_function	ATP hydrolysis activity
L	0022624	cellular_component	proteasome accessory complex
L	0030674	molecular_function	protein-macromolecule adaptor activity
L	0031597	cellular_component	cytosolic proteasome complex
L	0036402	molecular_function	proteasome-activating activity
L	0036503	biological_process	ERAD pathway
L	0042802	molecular_function	identical protein binding
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
L	0070062	cellular_component	extracellular exosome
L	0090261	biological_process	positive regulation of inclusion body assembly
L	1901800	biological_process	positive regulation of proteasomal protein catabolic process
M	0000166	molecular_function	nucleotide binding
M	0000502	cellular_component	proteasome complex
M	0000932	cellular_component	P-body
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005576	cellular_component	extracellular region
M	0005634	cellular_component	nucleus
M	0005654	cellular_component	nucleoplasm
M	0005737	cellular_component	cytoplasm
M	0005829	cellular_component	cytosol
M	0008540	cellular_component	proteasome regulatory particle, base subcomplex
M	0016020	cellular_component	membrane
M	0016887	molecular_function	ATP hydrolysis activity
M	0022624	cellular_component	proteasome accessory complex
M	0034774	cellular_component	secretory granule lumen
M	0036402	molecular_function	proteasome-activating activity
M	0042802	molecular_function	identical protein binding
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0043921	biological_process	modulation by host of viral transcription
M	0045944	biological_process	positive regulation of transcription by RNA polymerase II
M	1901800	biological_process	positive regulation of proteasomal protein catabolic process
M	1904813	cellular_component	ficolin-1-rich granule lumen
N	0000502	cellular_component	proteasome complex
N	0000932	cellular_component	P-body
N	0003723	molecular_function	RNA binding
N	0004175	molecular_function	endopeptidase activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0005654	cellular_component	nucleoplasm
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005839	cellular_component	proteasome core complex
N	0005840	cellular_component	ribosome
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
N	0010498	biological_process	proteasomal protein catabolic process
N	0016363	cellular_component	nuclear matrix
N	0019773	cellular_component	proteasome core complex, alpha-subunit complex
N	0030016	cellular_component	myofibril
N	0030017	cellular_component	sarcomere
N	0035639	molecular_function	purine ribonucleoside triphosphate binding
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0050727	biological_process	regulation of inflammatory response
N	0051059	molecular_function	NF-kappaB binding
N	0051092	biological_process	positive regulation of NF-kappaB transcription factor activity
N	0051603	biological_process	proteolysis involved in protein catabolic process
N	0070062	cellular_component	extracellular exosome
O	0000502	cellular_component	proteasome complex
O	0000932	cellular_component	P-body
O	0005515	molecular_function	protein binding
O	0005576	cellular_component	extracellular region
O	0005634	cellular_component	nucleus
O	0005654	cellular_component	nucleoplasm
O	0005737	cellular_component	cytoplasm
O	0005829	cellular_component	cytosol
O	0005839	cellular_component	proteasome core complex
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0009615	biological_process	response to virus
O	0010498	biological_process	proteasomal protein catabolic process
O	0019773	cellular_component	proteasome core complex, alpha-subunit complex
O	0034774	cellular_component	secretory granule lumen
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0051603	biological_process	proteolysis involved in protein catabolic process
O	0070062	cellular_component	extracellular exosome
O	1904813	cellular_component	ficolin-1-rich granule lumen
P	0000502	cellular_component	proteasome complex
P	0000932	cellular_component	P-body
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005654	cellular_component	nucleoplasm
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005839	cellular_component	proteasome core complex
P	0006511	biological_process	ubiquitin-dependent protein catabolic process
P	0010498	biological_process	proteasomal protein catabolic process
P	0019773	cellular_component	proteasome core complex, alpha-subunit complex
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
P	0043231	cellular_component	intracellular membrane-bounded organelle
P	0051603	biological_process	proteolysis involved in protein catabolic process
P	0070062	cellular_component	extracellular exosome
Q	0000502	cellular_component	proteasome complex
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005654	cellular_component	nucleoplasm
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0005839	cellular_component	proteasome core complex
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0010498	biological_process	proteasomal protein catabolic process
Q	0019773	cellular_component	proteasome core complex, alpha-subunit complex
Q	0042802	molecular_function	identical protein binding
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0051603	biological_process	proteolysis involved in protein catabolic process
Q	0070062	cellular_component	extracellular exosome
Q	0098794	cellular_component	postsynapse
R	0000502	cellular_component	proteasome complex
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0005839	cellular_component	proteasome core complex
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0010498	biological_process	proteasomal protein catabolic process
R	0019773	cellular_component	proteasome core complex, alpha-subunit complex
R	0034774	cellular_component	secretory granule lumen
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0051603	biological_process	proteolysis involved in protein catabolic process
R	0070062	cellular_component	extracellular exosome
R	1904813	cellular_component	ficolin-1-rich granule lumen
S	0000502	cellular_component	proteasome complex
S	0001530	molecular_function	lipopolysaccharide binding
S	0002376	biological_process	immune system process
S	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005813	cellular_component	centrosome
S	0005829	cellular_component	cytosol
S	0005839	cellular_component	proteasome core complex
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0010498	biological_process	proteasomal protein catabolic process
S	0019773	cellular_component	proteasome core complex, alpha-subunit complex
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0051603	biological_process	proteolysis involved in protein catabolic process
S	0070062	cellular_component	extracellular exosome
T	0000502	cellular_component	proteasome complex
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005654	cellular_component	nucleoplasm
T	0005737	cellular_component	cytoplasm
T	0005829	cellular_component	cytosol
T	0005839	cellular_component	proteasome core complex
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0010498	biological_process	proteasomal protein catabolic process
T	0019773	cellular_component	proteasome core complex, alpha-subunit complex
T	0031625	molecular_function	ubiquitin protein ligase binding
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0045202	cellular_component	synapse
T	0051603	biological_process	proteolysis involved in protein catabolic process
T	0052548	biological_process	regulation of endopeptidase activity
T	0070062	cellular_component	extracellular exosome
U	0000502	cellular_component	proteasome complex
U	0005515	molecular_function	protein binding
U	0005576	cellular_component	extracellular region
U	0005634	cellular_component	nucleus
U	0005654	cellular_component	nucleoplasm
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005839	cellular_component	proteasome core complex
U	0019774	cellular_component	proteasome core complex, beta-subunit complex
U	0034774	cellular_component	secretory granule lumen
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0051603	biological_process	proteolysis involved in protein catabolic process
U	0070062	cellular_component	extracellular exosome
U	1904813	cellular_component	ficolin-1-rich granule lumen
V	0000502	cellular_component	proteasome complex
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005654	cellular_component	nucleoplasm
V	0005737	cellular_component	cytoplasm
V	0005829	cellular_component	cytosol
V	0005839	cellular_component	proteasome core complex
V	0010243	biological_process	response to organonitrogen compound
V	0010498	biological_process	proteasomal protein catabolic process
V	0014070	biological_process	response to organic cyclic compound
V	0016020	cellular_component	membrane
V	0019774	cellular_component	proteasome core complex, beta-subunit complex
V	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0051603	biological_process	proteolysis involved in protein catabolic process
V	0070062	cellular_component	extracellular exosome
W	0000502	cellular_component	proteasome complex
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0005737	cellular_component	cytoplasm
W	0005829	cellular_component	cytosol
W	0005839	cellular_component	proteasome core complex
W	0019774	cellular_component	proteasome core complex, beta-subunit complex
W	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
W	0051603	biological_process	proteolysis involved in protein catabolic process
W	0070062	cellular_component	extracellular exosome
X	0000502	cellular_component	proteasome complex
X	0001530	molecular_function	lipopolysaccharide binding
X	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
X	0005515	molecular_function	protein binding
X	0005634	cellular_component	nucleus
X	0005654	cellular_component	nucleoplasm
X	0005737	cellular_component	cytoplasm
X	0005739	cellular_component	mitochondrion
X	0005829	cellular_component	cytosol
X	0005839	cellular_component	proteasome core complex
X	0019774	cellular_component	proteasome core complex, beta-subunit complex
X	0036064	cellular_component	ciliary basal body
X	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
X	0051603	biological_process	proteolysis involved in protein catabolic process
X	0070062	cellular_component	extracellular exosome
Y	0000502	cellular_component	proteasome complex
Y	0004175	molecular_function	endopeptidase activity
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005515	molecular_function	protein binding
Y	0005634	cellular_component	nucleus
Y	0005654	cellular_component	nucleoplasm
Y	0005737	cellular_component	cytoplasm
Y	0005813	cellular_component	centrosome
Y	0005829	cellular_component	cytosol
Y	0005839	cellular_component	proteasome core complex
Y	0006508	biological_process	proteolysis
Y	0006979	biological_process	response to oxidative stress
Y	0008233	molecular_function	peptidase activity
Y	0016787	molecular_function	hydrolase activity
Y	0019774	cellular_component	proteasome core complex, beta-subunit complex
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0070062	cellular_component	extracellular exosome
Z	0000502	cellular_component	proteasome complex
Z	0004175	molecular_function	endopeptidase activity
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005654	cellular_component	nucleoplasm
Z	0005737	cellular_component	cytoplasm
Z	0005739	cellular_component	mitochondrion
Z	0005829	cellular_component	cytosol
Z	0005839	cellular_component	proteasome core complex
Z	0006508	biological_process	proteolysis
Z	0008233	molecular_function	peptidase activity
Z	0016787	molecular_function	hydrolase activity
Z	0019774	cellular_component	proteasome core complex, beta-subunit complex
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Z	0045296	molecular_function	cadherin binding
Z	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue ATP H 501

Chain	Residue
H	ASP176
H	ILE354
H	HIS358
H	GLY382
H	ALA383
H	MG502
I	ASP317
I	ARG343
I	ARG346
H	GLY178
H	GLY219
H	THR220
H	GLY221
H	LYS222
H	THR223
H	LEU224
H	ASN322

---

site_id	AC2
Number of Residues	2
Details	binding site for residue MG H 502

Chain	Residue
H	THR223
H	ATP501

---

site_id	AC3
Number of Residues	18
Details	binding site for residue ATP I 501

Chain	Residue
I	ASP186
I	GLY188
I	LEU190
I	PRO228
I	GLY229
I	THR230
I	GLY231
I	LYS232
I	THR233
I	LEU234
I	ILE364
I	HIS368
I	GLY392
I	ALA393
I	LYS396
I	MG502
J	ARG307
J	ARG310

---

site_id	AC4
Number of Residues	2
Details	binding site for residue MG I 502

Chain	Residue
I	THR233
I	ATP501

---

site_id	AC5
Number of Residues	18
Details	binding site for residue ATP K 501

Chain	Residue
K	ASP166
K	ILE167
K	GLY168
K	PRO208
K	GLY209
K	CYS210
K	GLY211
K	LYS212
K	THR213
K	MET214
K	ASN312
K	ILE344
K	GLY372
K	ALA373
K	ASN376
K	MG502
L	ARG291
L	ARG294

---

site_id	AC6
Number of Residues	4
Details	binding site for residue MG K 502

Chain	Residue
K	THR213
K	ASP265
K	ATP501
L	ASP265

---

site_id	AC7
Number of Residues	18
Details	binding site for residue ATP L 401

Chain	Residue
L	GLY136
L	PRO176
L	GLY177
L	THR178
L	GLY179
L	LYS180
L	THR181
L	LEU182
L	GLU234
L	ASN280
L	ILE312
L	HIS316
L	GLY340
L	ALA341
L	ARG344
L	MG402
M	ARG344
M	ARG347

---

site_id	AC8
Number of Residues	2
Details	binding site for residue MG L 402

Chain	Residue
L	THR181
L	ATP401

---

site_id	AC9
Number of Residues	20
Details	binding site for residue ATP M 501

Chain	Residue
M	LYS397
M	MG502
H	ARG333
H	ARG336
M	ILE188
M	GLY189
M	LEU191
M	PRO229
M	GLY230
M	THR231
M	GLY232
M	LYS233
M	THR234
M	LEU235
M	ARG238
M	ASN333
M	ILE365
M	HIS369
M	GLY393
M	ALA394

---

site_id	AD1
Number of Residues	2
Details	binding site for residue MG M 502

Chain	Residue
M	THR234
M	ATP501

---

site_id	AD2
Number of Residues	13
Details	binding site for residue ADP J 501

Chain	Residue
J	MET150
J	GLY152
J	PRO192
J	GLY193
J	THR194
J	GLY195
J	LYS196
J	THR197
J	LEU198
J	ILE328
J	HIS332
J	GLY356
J	ALA357

---

Functional Information from PROSITE/UniProt

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. AGVvYkdGIVLGADtrategmvvadkncs.KihfispniyccgaGtaAD

Chain	Residue	Details
7	ALA4-ASP51
6	MET4-ASP51
V	ILE5-ASP52
U	LEU13-ASP60
P	LEU35-ASP82
W	MET12-ASP59
Y	LEU4-ASP51
X	LEU12-ASP59

---

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. VkVIaATNrvdiLDpALl.R

Chain	Residue	Details
M	VAL326-ARG344
I	VAL325-ARG343
J	ILE289-ARG307
L	VAL273-ARG291
K	VAL305-ARG323
H	ILE315-ARG333

---

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdrgvNtFSPeGRlfQVEYAieA

Chain	Residue	Details
R	TYR8-ALA30
O	TYR5-ALA27
N	PHE9-ALA31
P	TYR5-ALA27
Q	TYR3-ALA25
S	TYR6-ALA28
T	TYR7-ALA29

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
J	GLY190
7	THR1
N	SER64
A	SER17
A	SER63
A	SER64

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:25489052, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378

Chain	Residue	Details
J	ALA2
L	LYS206
U	SER134
1	SER34
1	SER40
1	SER134

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
J	SER120
6	THR35
C	LYS127
C	LYS176
B	SER13
B	SER15

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
J	LYS222
1	LYS176

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17323924, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231

Chain	Residue	Details
K	SER28
U	SER181
1	SER30
1	SER181
F	LYS208

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
K	LYS397
K	LYS401

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	LIPID: N-myristoyl glycine => ECO:0000269|PubMed:22223895, ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:25807930

Chain	Residue	Details
I	GLY2
B	TYR120

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:17370265

Chain	Residue	Details
I	LYS237

---