5HCD

Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Rhipicephalus microplus RaCI2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	Complement C5	polymer	656	73518.6	1	UniProt (P01031) Pfam (PF17789) Pfam (PF07703) Pfam (PF17790) Pfam (PF01835) Pfam (PF17791) In PDB	Homo sapiens (Human)	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
2	A	Complement C5	polymer	998	112533.9	1	UniProt (P01031) Pfam (PF01821) Pfam (PF00207) Pfam (PF07678) Pfam (PF21309) Pfam (PF07677) Pfam (PF01759) In PDB	Homo sapiens (Human)	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
3	C	Complement inhibitor	polymer	165	18647.6	1	UniProt (Q5YD59) In PDB	Ornithodoros moubata (Soft tick)
4	D	Rhipicephalus microplus RaCI2	polymer	80	8659.7	1	UniProt (by SIFTS) (A0A158RFT4) In PDB	Rhipicephalus microplus
5	E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6	A	CYSTEINE	non-polymer		121.2	1	Chemie (CYS)

Sequence modifications

C: 19 - 168 (UniProt: Q5YD59)

PDB	External Database	Details
Met 4	-	initiating methionine
Ala 5	-	expression tag
Ser 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
His 12	-	expression tag
His 13	-	expression tag
His 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
Ser 17	-	expression tag
Gly 18	-	expression tag
Gln 78	Asn 78	engineered mutation
Gln 102	Asn 102	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	213359.8
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	1
	Total formula weight	121.2
All*	Total formula weight	213905.4

*Water molecules are not included.