5HCC
Ternary complex of human Complement C5 with Ornithodoros moubata OmCI and Dermacentor andersoni RaCI3.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | Complement C5 | polymer | 656 | 73518.6 | 1 | UniProt (P01031) Pfam (PF17789) Pfam (PF07703) Pfam (PF17790) Pfam (PF01835) Pfam (PF17791) In PDB | Homo sapiens (Human) | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 |
| 2 | A | Complement C5 | polymer | 998 | 112533.9 | 1 | UniProt (P01031) Pfam (PF01821) Pfam (PF00207) Pfam (PF07678) Pfam (PF21309) Pfam (PF07677) Pfam (PF01759) In PDB | Homo sapiens (Human) | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 |
| 3 | C | Complement inhibitor | polymer | 165 | 18647.6 | 1 | UniProt (Q5YD59) In PDB | Ornithodoros moubata (Soft tick) | |
| 4 | D | Dermacentor andersoni RaCI3 | polymer | 81 | 8673.5 | 1 | UniProt (by SIFTS) (A0A146B485) In PDB | Dermacentor andersoni | |
| 5 | E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 6 | B, A, C, D | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 7 | A | CYSTEINE | non-polymer | 121.2 | 1 | Chemie (CYS) | |||
| 8 | A | 1,4-DIETHYLENE DIOXIDE | non-polymer | 88.1 | 1 | Chemie (DIO) | |||
| 9 | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
C: 19 - 168 (UniProt: Q5YD59)
| PDB | External Database | Details |
|---|---|---|
| Met 4 | - | initiating methionine |
| Ala 5 | - | expression tag |
| Ser 6 | - | expression tag |
| His 7 | - | expression tag |
| His 8 | - | expression tag |
| His 9 | - | expression tag |
| His 10 | - | expression tag |
| His 11 | - | expression tag |
| His 12 | - | expression tag |
| His 13 | - | expression tag |
| His 14 | - | expression tag |
| His 15 | - | expression tag |
| His 16 | - | expression tag |
| Ser 17 | - | expression tag |
| Gly 18 | - | expression tag |
| Gln 78 | Asn 78 | engineered mutation |
| Gln 102 | Asn 102 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 213373.6 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 643.7 | |
| All* | Total formula weight | 214441.8 |
