5FL4
Three dimensional structure of human carbonic anhydrase IX in complex with 5-(1-naphthalen-1-yl-1,2,3-triazol-4-yl)thiophene-2-sulfonamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | CARBONIC ANHYDRASE 9 | polymer | 257 | 28172.7 | 4 | UniProt (Q16790) Pfam (PF00194) | HOMO SAPIENS (HUMAN) | CARBONATE DEHYDRATASE IX, CARBONIC ANHYDRASE IX, CA-IX, CAIX, MEMBRANE ANTIGEN MN, P54/58N, RENAL CELL CARCINOMA-ASSOCIATED ANTIGEN G250, RCC-ASSOCIATED ANTIGEN G250, PMW1 |
| 2 | E, J, N, T (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, K, O, U (A, B, C, D) | 5-(1-naphthalen-1-yl-1,2,3-triazol-4-yl)thiophene-2-sulfonamide | non-polymer | 356.4 | 4 | Chemie (9FK) | |||
| 4 | G, L, P, V (A, B, C, D) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | H, I, M, Q, R... (A, B, C) | ACETIC ACID | non-polymer | 60.1 | 6 | Chemie (ACY) | |||
| 6 | W, X, Y, Z (A, B, C, D) | water | water | 18.0 | 1050 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 5 - 259 (UniProt: Q16790)
| PDB | External Database | Details |
|---|---|---|
| Gly 3 | - | expression tag |
| Pro 4 | - | expression tag |
| Ser 42 | Cys 174 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 112690.7 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2416.0 | |
| All* | Total formula weight | 115106.7 |
