5FL4

Three dimensional structure of human carbonic anhydrase IX in complex with 5-(1-naphthalen-1-yl-1,2,3-triazol-4-yl)thiophene-2-sulfonamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004089	molecular_function	carbonate dehydratase activity
A	0008270	molecular_function	zinc ion binding
B	0004089	molecular_function	carbonate dehydratase activity
B	0008270	molecular_function	zinc ion binding
C	0004089	molecular_function	carbonate dehydratase activity
C	0008270	molecular_function	zinc ion binding
D	0004089	molecular_function	carbonate dehydratase activity
D	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 264

Chain	Residue
A	HIS94
A	HIS96
A	HIS119
A	9FK269
A	GOL273

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 9FK A 269

Chain	Residue
A	VAL130
A	LEU134
A	LEU199
A	THR200
A	THR201
A	TRP210
A	ZN264
A	GOL273
A	HOH2348
C	ARG129
A	GLN92
A	HIS94
A	HIS96
A	HIS119

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 273

Chain	Residue
A	ASN66
A	HIS68
A	SER69
A	GLN71
A	GLN92
A	HIS94
A	THR201
A	ZN264
A	9FK269
A	HOH2005
A	HOH2134

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 264

Chain	Residue
B	HIS94
B	HIS96
B	HIS119
B	9FK268

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 9FK B 268

Chain	Residue
B	HIS94
B	HIS96
B	HIS119
B	LEU134
B	LEU199
B	THR200
B	THR201
B	TRP210
B	ZN264
B	GOL272
B	HOH2143

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B 272

Chain	Residue
B	ASN66
B	HIS68
B	SER69
B	GLN71
B	GLN92
B	HIS94
B	9FK268
B	HOH2005
B	HOH2244

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 264

Chain	Residue
C	HIS94
C	HIS96
C	HIS119
C	9FK267

---

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 9FK C 267

Chain	Residue
A	ARG129
C	GLN92
C	HIS94
C	HIS96
C	HIS119
C	VAL121
C	VAL130
C	ASP131
C	LEU134
C	LEU199
C	THR200
C	THR201
C	TRP210
C	ZN264
C	GOL271

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL C 271

Chain	Residue
C	ASN66
C	HIS68
C	GLN71
C	GLN92
C	HIS94
C	THR201
C	9FK267
C	HOH2005
C	HOH2224

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 264

Chain	Residue
D	HIS94
D	HIS96
D	HIS119
D	9FK266

---

site_id	BC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 9FK D 266

Chain	Residue
D	HIS94
D	HIS96
D	HIS119
D	LEU134
D	LEU199
D	THR200
D	THR201
D	TRP210
D	ZN264
D	GOL271
D	HOH2102

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL D 271

Chain	Residue
D	SER69
D	GLN71
D	GLN92
D	HIS94
D	9FK266
D	HOH2003
D	ASN66
D	HIS68

---

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACY A 1260

Chain	Residue
A	GLY98
A	ALA99
A	ARG102
A	PRO115
A	LEU224
A	SER228
A	HOH2350

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACY B 1260

Chain	Residue
B	HIS112
B	HOH2161

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY C 1260

Chain	Residue
B	SER187
B	HOH2253
C	PRO248
C	LEU249
C	ASN250

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY C 1261

Chain	Residue
B	HOH2225
C	ARG27
C	PHE28
C	ASN250
C	HOH2225

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACY A 1261

Chain	Residue
A	LEU249
A	ASN250
A	HOH2340
A	HOH2351
A	HOH2352
D	SER187

---

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACY C 1262

Chain	Residue
C	PHE28
C	GLU196
C	GLY197
C	GLN206
C	GLY207
C	HOH2202
C	HOH2226
D	PRO84

---

Functional Information from PROSITE/UniProt

site_id	PS00162
Number of Residues	17
Details	ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVeghrFpaEIHVV

Chain	Residue	Details
A	SER105-VAL121

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19805286","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"18703501","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19805286","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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