5E4E
Engineered Interleukin-13 bound to receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Interleukin-13 | polymer | 113 | 12463.4 | 1 | UniProt (P35225) Pfam (PF03487) | Homo sapiens (Human) | IL-13 |
| 2 | B (B) | Interleukin-4 receptor subunit alpha | polymer | 203 | 23212.1 | 1 | UniProt (P24394) Pfam (PF09238) | Homo sapiens (Human) | IL-4RA |
| 3 | C (C) | Interleukin-13 receptor subunit alpha-1 | polymer | 318 | 36571.0 | 1 | UniProt (P78552) Pfam (PF18001) Pfam (PF09240) | Homo sapiens (Human) | IL-13RA1,Cancer/testis antigen 19,CT19 |
| 4 | D, E, F, G, J... (A, C) | SULFATE ION | non-polymer | 96.1 | 7 | Chemie (SO4) | |||
| 5 | H, I (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
A: 1 - 113 (UniProt: P35225)
| PDB | External Database | Details |
|---|---|---|
| Val 10 | Leu 43 | engineered mutation |
| Ile 18 | Val 51 | engineered mutation |
| Arg 39 | Leu 72 | engineered mutation |
| Ser 87 | Asp 120 | engineered mutation |
| Ser 88 | Thr 121 | engineered mutation |
| Phe 101 | Leu 134 | engineered mutation |
| Arg 104 | Lys 137 | engineered mutation |
| Thr 105 | Lys 138 | engineered mutation |
| Gln 111 | Arg 144 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 72246.4 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1114.9 | |
| All* | Total formula weight | 73361.3 |
