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5E4E

Engineered Interleukin-13 bound to receptor

Functional Information from GO Data
ChainGOidnamespacecontents
A0001774biological_processmicroglial cell activation
A0002639biological_processpositive regulation of immunoglobulin production
A0005125molecular_functioncytokine activity
A0005126molecular_functioncytokine receptor binding
A0005144molecular_functioninterleukin-13 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007179biological_processtransforming growth factor beta receptor signaling pathway
A0009612biological_processresponse to mechanical stimulus
A0009624biological_processresponse to nematode
A0009897cellular_componentexternal side of plasma membrane
A0010155biological_processregulation of proton transport
A0010269biological_processresponse to selenium ion
A0010628biological_processpositive regulation of gene expression
A0030890biological_processpositive regulation of B cell proliferation
A0032496biological_processresponse to lipopolysaccharide
A0032733biological_processpositive regulation of interleukin-10 production
A0032905biological_processtransforming growth factor beta1 production
A0035094biological_processresponse to nicotine
A0035772biological_processinterleukin-13-mediated signaling pathway
A0042116biological_processmacrophage activation
A0043032biological_processpositive regulation of macrophage activation
A0043270biological_processpositive regulation of monoatomic ion transport
A0043306biological_processpositive regulation of mast cell degranulation
A0045471biological_processresponse to ethanol
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0050714biological_processpositive regulation of protein secretion
A0050728biological_processnegative regulation of inflammatory response
A0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
A0071260biological_processcellular response to mechanical stimulus
A0071345biological_processcellular response to cytokine stimulus
A0071635biological_processnegative regulation of transforming growth factor beta production
A0120162biological_processpositive regulation of cold-induced thermogenesis
A1901247biological_processnegative regulation of lung ciliated cell differentiation
A1901251biological_processpositive regulation of lung goblet cell differentiation
A1903660biological_processnegative regulation of complement-dependent cytotoxicity
A2000231biological_processpositive regulation of pancreatic stellate cell proliferation
A2000352biological_processnegative regulation of endothelial cell apoptotic process
B0002532biological_processproduction of molecular mediator involved in inflammatory response
B0004896molecular_functioncytokine receptor activity
B0016020cellular_componentmembrane
C0004896molecular_functioncytokine receptor activity
C0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS01355
Number of Residues31
DetailsHEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. LksgisyrarVRawaqcyntt...........WSeWSpstkW
ChainResidueDetails
BLEU166-TRP196

site_idPS01356
Number of Residues32
DetailsHEMATOPO_REC_S_F2 Short hematopoietin receptor family 2 signature. MkCsWlpGrntspDtnYtLyywhrslekihq..C
ChainResidueDetails
CMET142-CYS173

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN37
CASN61
CASN105
CASN138
CASN157
CASN235
CASN265
CASN293
CASN329

site_idSWS_FT_FI2
Number of Residues5
DetailsSITE: Minor IL4 binding determinant
ChainResidueDetails
BLEU39
BPHE41
BASP67
BVAL69
BTYR127

site_idSWS_FT_FI3
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN28
BASN73
BASN103
BASN109
BASN151
BASN184

237735

PDB entries from 2025-06-18

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