5CQD
Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | DNA dC->dU-editing enzyme APOBEC-3B | polymer | 186 | 21979.0 | 2 | UniProt (Q9UH17) Pfam (PF05240) In PDB | Homo sapiens (Human) | A3B,Phorbolin-1-related protein,Phorbolin-2/3 |
| 2 | A, C | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | A, C | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 4 | water | water | 18.0 | 75 | Chemie (HOH) |
Sequence modifications
A, C: 187 - 378 (UniProt: Q9UH17)
| PDB | External Database | Details |
|---|---|---|
| Met 186 | - | initiating methionine |
| Ser 200 | Phe 200 | engineered mutation |
| Ser 228 | Trp 228 | engineered mutation |
| Lys 230 | Leu 230 | engineered mutation |
| - | Ala 242 | deletion |
| - | Lys 243 | deletion |
| - | Asn 244 | deletion |
| - | Leu 245 | deletion |
| - | Leu 246 | deletion |
| - | Cys 247 | deletion |
| - | Gly 248 | deletion |
| - | Phe 249 | deletion |
| Ser 250 | Tyr 250 | engineered mutation |
| Lys 308 | Phe 308 | engineered mutation |
| Leu 379 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43957.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 591.3 | |
| All* | Total formula weight | 44549.2 |
