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5CQD

Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0008270molecular_functionzinc ion binding
A0016787molecular_functionhydrolase activity
C0003824molecular_functioncatalytic activity
C0008270molecular_functionzinc ion binding
C0016787molecular_functionhydrolase activity
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue ZN A 501
ChainResidue
AHIS253
ACYS284
ACYS289
AGOL502
AHOH603

site_idAC2
Number of Residues11
Detailsbinding site for residue GOL A 502
ChainResidue
AASN240
AHIS253
ATRP281
ATYR313
AZN501
AHOH601
AHOH603
AARG211
AARG212
AGLN213
ATHR214

site_idAC3
Number of Residues1
Detailsbinding site for residue GOL A 503
ChainResidue
ASER286

site_idAC4
Number of Residues5
Detailsbinding site for residue GOL A 504
ChainResidue
ACYS239
AGLU241
AARG257
AHOH612
AHOH631

site_idAC5
Number of Residues2
Detailsbinding site for residue GOL A 505
ChainResidue
AGLU342
AASP346

site_idAC6
Number of Residues4
Detailsbinding site for residue ZN C 501
ChainResidue
CHIS253
CCYS284
CCYS289
CHOH602

site_idAC7
Number of Residues8
Detailsbinding site for residue GOL C 502
ChainResidue
CARG211
CARG212
CGLN213
CTHR214
CASN240
CHIS253
CTYR313
CHOH602

Functional Information from PROSITE/UniProt
site_idPS00903
Number of Residues41
DetailsCYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAElrFLdlvpslqldpaqiyrvtwfisws..........PCfswg....CageV
ChainResidueDetails
AHIS253-VAL293

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000255
ChainResidueDetails
APRO263
CPRO263

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
ALEU261
AGLU292
ALEU297
CLEU261
CGLU292
CLEU297

226707

PDB entries from 2024-10-30

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