5CQD

Crystal Structure of the Cancer Genomic DNA Mutator APOBEC3B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
C	0003824	molecular_function	catalytic activity
C	0008270	molecular_function	zinc ion binding
C	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN A 501

Chain	Residue
A	HIS253
A	CYS284
A	CYS289
A	GOL502
A	HOH603

---

site_id	AC2
Number of Residues	11
Details	binding site for residue GOL A 502

Chain	Residue
A	ASN240
A	HIS253
A	TRP281
A	TYR313
A	ZN501
A	HOH601
A	HOH603
A	ARG211
A	ARG212
A	GLN213
A	THR214

---

site_id	AC3
Number of Residues	1
Details	binding site for residue GOL A 503

Chain	Residue
A	SER286

---

site_id	AC4
Number of Residues	5
Details	binding site for residue GOL A 504

Chain	Residue
A	CYS239
A	GLU241
A	ARG257
A	HOH612
A	HOH631

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site_id	AC5
Number of Residues	2
Details	binding site for residue GOL A 505

Chain	Residue
A	GLU342
A	ASP346

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN C 501

Chain	Residue
C	HIS253
C	CYS284
C	CYS289
C	HOH602

---

site_id	AC7
Number of Residues	8
Details	binding site for residue GOL C 502

Chain	Residue
C	ARG211
C	ARG212
C	GLN213
C	THR214
C	ASN240
C	HIS253
C	TYR313
C	HOH602

---

Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	41
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAElrFLdlvpslqldpaqiyrvtwfisws..........PCfswg....CageV

Chain	Residue	Details
A	HIS253-VAL293

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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