5CKX

Non-covalent complex of DAHP synthase and chorismate mutase from Mycobacterium tuberculosis with bound transition state analog and feedback effectors tyrosine and phenylalanine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Phospho-2-dehydro-3-deoxyheptonate aldolase AroG	polymer	472	51891.5	2	UniProt (O53512) Pfam (PF01474) In PDB	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	3-deoxy-D-arabino-heptulosonate 7-phosphate synthase,DAHP synthase,Phospho-2-keto-3-deoxyheptonate aldolase
2	C, D	Intracellular chorismate mutase	polymer	90	10107.8	2	UniProt (P9WIC1) Pfam (PF01817) In PDB	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	CM
3	A, B	MANGANESE (II) ION	non-polymer		54.9	2	Chemie (MN)
4	A, B, D	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
5	A, B	CHLORIDE ION	non-polymer		35.5	3	Chemie (CL)
6	A, B, C, D	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
7	A, B	PHENYLALANINE	non-polymer		165.2	2	Chemie (PHE)
8	B	TYROSINE	non-polymer		181.2	1	Chemie (TYR)
9	D, C	8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC ACID	non-polymer		228.2	2	Chemie (TSA)
10		water	water		18.0	39	Chemie (HOH)

Sequence modifications

A, B: 1 - 462 (UniProt: O53512)

PDB	External Database	Details
Met -9	-	initiating methionine
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
Ser -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	123998.7
Non-Polymers*	Number of molecules	23
	Total formula weight	2413.2
All*	Total formula weight	126411.9

*Water molecules are not included.