5CKX
Non-covalent complex of DAHP synthase and chorismate mutase from Mycobacterium tuberculosis with bound transition state analog and feedback effectors tyrosine and phenylalanine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Phospho-2-dehydro-3-deoxyheptonate aldolase AroG | polymer | 472 | 51891.5 | 2 | UniProt (O53512) Pfam (PF01474) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase,DAHP synthase,Phospho-2-keto-3-deoxyheptonate aldolase |
| 2 | C, D (C, D) | Intracellular chorismate mutase | polymer | 90 | 10107.8 | 2 | UniProt (P9WIC1) Pfam (PF01817) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | CM |
| 3 | E, N (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 4 | F, O, P, Q, Y (A, B, D) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 5 | G, H, R (A, B) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 6 | I, J, K, L, S... (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 7 | M, U (A, B) | PHENYLALANINE | non-polymer | 165.2 | 2 | Chemie (PHE) | |||
| 8 | V (B) | TYROSINE | non-polymer | 181.2 | 1 | Chemie (TYR) | |||
| 9 | AA, X (D, C) | 8-HYDROXY-2-OXA-BICYCLO[3.3.1]NON-6-ENE-3,5-DICARBOXYLIC ACID | non-polymer | 228.2 | 2 | Chemie (TSA) | |||
| 10 | BA, CA (A, B) | water | water | 18.0 | 39 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 462 (UniProt: O53512)
| PDB | External Database | Details |
|---|---|---|
| Met -9 | - | initiating methionine |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 123998.7 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 2413.2 | |
| All* | Total formula weight | 126411.9 |
