5CKX
Non-covalent complex of DAHP synthase and chorismate mutase from Mycobacterium tuberculosis with bound transition state analog and feedback effectors tyrosine and phenylalanine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0009423 | biological_process | chorismate biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051260 | biological_process | protein homooligomerization |
| B | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0009423 | biological_process | chorismate biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051260 | biological_process | protein homooligomerization |
| C | 0046417 | biological_process | chorismate metabolic process |
| D | 0046417 | biological_process | chorismate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue MN A 501 |
| Chain | Residue |
| A | CYS87 |
| A | HIS369 |
| A | GLU411 |
| A | ASP441 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | GLU63 |
| A | MET180 |
| A | THR187 |
| A | ILE243 |
| A | HIS277 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 503 |
| Chain | Residue |
| A | GLN36 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 504 |
| Chain | Residue |
| A | ASP150 |
| A | ARG168 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 505 |
| Chain | Residue |
| A | GLY282 |
| A | GLU283 |
| A | LYS306 |
| A | ARG337 |
| A | HIS369 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 506 |
| Chain | Residue |
| A | ARG223 |
| A | ARG461 |
| A | ASP462 |
| C | ARG82 |
| C | ARG87 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 507 |
| Chain | Residue |
| A | ARG135 |
| A | SER136 |
| A | ARG284 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 508 |
| Chain | Residue |
| A | VAL60 |
| A | PRO61 |
| A | SER62 |
| B | ARG100 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue PHE A 509 |
| Chain | Residue |
| A | PHE91 |
| A | ARG171 |
| A | ASN175 |
| A | HOH605 |
| B | VAL5 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue MN B 501 |
| Chain | Residue |
| B | CYS87 |
| B | HIS369 |
| B | GLU411 |
| B | ASP441 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| B | GLU63 |
| B | ARG66 |
| B | MET180 |
| B | THR187 |
| B | ALA241 |
| B | ILE243 |
| B | HOH614 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 503 |
| Chain | Residue |
| B | ALA110 |
| B | THR114 |
| B | PRO120 |
| B | VAL121 |
| B | LYS123 |
| B | ALA230 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 504 |
| Chain | Residue |
| B | GLN70 |
| B | VAL121 |
| B | VAL122 |
| B | GLU242 |
| B | HOH609 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue CL B 505 |
| Chain | Residue |
| B | PRO61 |
| B | SER62 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 506 |
| Chain | Residue |
| B | GLY282 |
| B | GLU283 |
| B | ARG284 |
| B | LYS306 |
| B | ARG337 |
| B | HIS369 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 507 |
| Chain | Residue |
| B | ARG135 |
| B | SER136 |
| B | ARG284 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue PHE B 508 |
| Chain | Residue |
| B | PHE91 |
| B | ARG171 |
| B | ASN175 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue TYR B 509 |
| Chain | Residue |
| B | PRO16 |
| B | LEU18 |
| B | ARG23 |
| B | GLU53 |
| B | ARG256 |
| B | LEU259 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 101 |
| Chain | Residue |
| C | ARG18 |
| C | VAL55 |
| site_id | AE2 |
| Number of Residues | 11 |
| Details | binding site for residue TSA C 102 |
| Chain | Residue |
| C | ARG18 |
| C | ARG35 |
| C | SER39 |
| C | ILE42 |
| C | ARG46 |
| C | LEU54 |
| C | VAL55 |
| C | ARG58 |
| C | GLU59 |
| C | VAL62 |
| C | LEU81 |
| site_id | AE3 |
| Number of Residues | 2 |
| Details | binding site for residue GOL D 101 |
| Chain | Residue |
| D | ARG18 |
| D | ARG46 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 D 102 |
| Chain | Residue |
| B | ARG223 |
| B | ARG461 |
| B | ASP462 |
| D | ARG82 |
| D | ARG87 |
| site_id | AE5 |
| Number of Residues | 12 |
| Details | binding site for residue TSA D 103 |
| Chain | Residue |
| D | ILE42 |
| D | ARG46 |
| D | LEU54 |
| D | VAL55 |
| D | ARG58 |
| D | GLU59 |
| D | VAL62 |
| D | LEU81 |
| D | ARG85 |
| D | ARG18 |
| D | ARG35 |
| D | SER39 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:19556970, ECO:0007744|PDB:2VKL |
| Chain | Residue | Details |
| C | ARG46 | |
| B | ARG126 | |
| B | GLU283 | |
| B | LYS306 | |
| B | ARG337 | |
| B | HIS369 | |
| B | GLU411 | |
| B | ASP441 | |
| C | VAL55 | |
| C | GLU59 | |
| D | ARG46 | |
| D | VAL55 | |
| D | GLU59 | |
| A | GLU411 | |
| A | ASP441 | |
| B | CYS87 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Important for catalysis => ECO:0000269|PubMed:19556970 |
| Chain | Residue | Details |
| C | ARG46 | |
| D | ARG46 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | SITE: Important for activation via AroG => ECO:0000269|PubMed:19556970 |
| Chain | Residue | Details |
| C | GLY86 | |
| C | ARG87 | |
| C | LEU88 | |
| D | GLY86 | |
| D | ARG87 | |
| D | LEU88 |
