5BQE
Crystal structure of Norrin in complex with the cysteine-rich domain of Frizzled 4 -Methylated form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Norrin | polymer | 122 | 13614.7 | 1 | UniProt (Q00604) Pfam (PF00007) | Homo sapiens (Human) | Norrie disease protein,X-linked exudative vitreoretinopathy 2 protein |
| 2 | B (B) | Norrin | polymer | 122 | 13722.9 | 1 | UniProt (Q00604) Pfam (PF00007) | Homo sapiens (Human) | Norrie disease protein,X-linked exudative vitreoretinopathy 2 protein |
| 3 | C (C) | Frizzled-4 | polymer | 149 | 16759.3 | 1 | UniProt (Q9ULV1) Pfam (PF01392) | Homo sapiens (Human) | hFz4,FzE4 |
| 4 | D, E, H (B, C) | 2-(2-METHOXYETHOXY)ETHANOL | non-polymer | 120.1 | 3 | Chemie (PG0) | |||
| 5 | F (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | G (C) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | I, J, K (A, B, C) | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence modifications
A: 25 - 133 (UniProt: Q00604)
B: 25 - 133 (UniProt: Q00604)
C: 42 - 179 (UniProt: Q9ULV1)
| PDB | External Database | Details |
|---|---|---|
| Gly 22 | - | expression tag |
| Pro 23 | - | expression tag |
| Gly 24 | - | expression tag |
| Gly 134 | - | expression tag |
| Thr 135 | - | expression tag |
| Glu 136 | - | expression tag |
| Thr 137 | - | expression tag |
| Ser 138 | - | expression tag |
| Gln 139 | - | expression tag |
| Val 140 | - | expression tag |
| Ala 141 | - | expression tag |
| Pro 142 | - | expression tag |
| Ala 143 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 22 | - | expression tag |
| Pro 23 | - | expression tag |
| Gly 24 | - | expression tag |
| Gly 134 | - | expression tag |
| Thr 135 | - | expression tag |
| Glu 136 | - | expression tag |
| Thr 137 | - | expression tag |
| Ser 138 | - | expression tag |
| Gln 139 | - | expression tag |
| Val 140 | - | expression tag |
| Ala 141 | - | expression tag |
| Pro 142 | - | expression tag |
| Ala 143 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 39 | - | expression tag |
| Thr 40 | - | expression tag |
| Gly 41 | - | expression tag |
| Gly 180 | - | expression tag |
| Thr 181 | - | expression tag |
| Leu 182 | - | expression tag |
| Glu 183 | - | expression tag |
| Val 184 | - | expression tag |
| Leu 185 | - | expression tag |
| Phe 186 | - | expression tag |
| Gln 187 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 44096.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 617.1 | |
| All* | Total formula weight | 44714.0 |
