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5BQE

Crystal structure of Norrin in complex with the cysteine-rich domain of Frizzled 4 -Methylated form

Functional Information from GO Data
ChainGOidnamespacecontents
A0000278biological_processmitotic cell cycle
A0000320biological_processre-entry into mitotic cell cycle
A0001508biological_processaction potential
A0001525biological_processangiogenesis
A0001666biological_processresponse to hypoxia
A0001890biological_processplacenta development
A0001974biological_processblood vessel remodeling
A0002088biological_processlens development in camera-type eye
A0003406biological_processretinal pigment epithelium development
A0003407biological_processneural retina development
A0005109molecular_functionfrizzled binding
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006099biological_processtricarboxylic acid cycle
A0006366biological_processtranscription by RNA polymerase II
A0006544biological_processglycine metabolic process
A0006622biological_processprotein targeting to lysosome
A0006749biological_processglutathione metabolic process
A0006954biological_processinflammatory response
A0007033biological_processvacuole organization
A0007179biological_processtransforming growth factor beta receptor signaling pathway
A0007224biological_processsmoothened signaling pathway
A0007399biological_processnervous system development
A0007601biological_processvisual perception
A0008104biological_processprotein localization
A0008283biological_processcell population proliferation
A0009069biological_processserine family amino acid metabolic process
A0009986cellular_componentcell surface
A0010467biological_processgene expression
A0010842biological_processretina layer formation
A0014004biological_processmicroglia differentiation
A0016055biological_processWnt signaling pathway
A0016358biological_processdendrite development
A0016567biological_processprotein ubiquitination
A0021554biological_processoptic nerve development
A0030182biological_processneuron differentiation
A0031290biological_processretinal ganglion cell axon guidance
A0035426biological_processextracellular matrix-cell signaling
A0035640biological_processexploration behavior
A0042803molecular_functionprotein homodimerization activity
A0045446biological_processendothelial cell differentiation
A0045893biological_processpositive regulation of DNA-templated transcription
A0046697biological_processdecidualization
A0048678biological_processresponse to axon injury
A0051402biological_processneuron apoptotic process
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0060041biological_processretina development in camera-type eye
A0060042biological_processretina morphogenesis in camera-type eye
A0060070biological_processcanonical Wnt signaling pathway
A0060221biological_processretinal rod cell differentiation
A0060856biological_processestablishment of blood-brain barrier
A0060996biological_processdendritic spine development
A0061298biological_processretina vasculature development in camera-type eye
A0061299biological_processretina vasculature morphogenesis in camera-type eye
A0061304biological_processretinal blood vessel morphogenesis
A0061518biological_processmicroglial cell proliferation
A0062023cellular_componentcollagen-containing extracellular matrix
A0070086biological_processubiquitin-dependent endocytosis
A0071456biological_processcellular response to hypoxia
A0097601biological_processretina blood vessel maintenance
A0110135biological_processNorrin signaling pathway
A1904390biological_processcone retinal bipolar cell differentiation
A1990963biological_processestablishment of blood-retinal barrier
B0000278biological_processmitotic cell cycle
B0000320biological_processre-entry into mitotic cell cycle
B0001508biological_processaction potential
B0001525biological_processangiogenesis
B0001666biological_processresponse to hypoxia
B0001890biological_processplacenta development
B0001974biological_processblood vessel remodeling
B0002088biological_processlens development in camera-type eye
B0003406biological_processretinal pigment epithelium development
B0003407biological_processneural retina development
B0005109molecular_functionfrizzled binding
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006099biological_processtricarboxylic acid cycle
B0006366biological_processtranscription by RNA polymerase II
B0006544biological_processglycine metabolic process
B0006622biological_processprotein targeting to lysosome
B0006749biological_processglutathione metabolic process
B0006954biological_processinflammatory response
B0007033biological_processvacuole organization
B0007179biological_processtransforming growth factor beta receptor signaling pathway
B0007224biological_processsmoothened signaling pathway
B0007399biological_processnervous system development
B0007601biological_processvisual perception
B0008104biological_processprotein localization
B0008283biological_processcell population proliferation
B0009069biological_processserine family amino acid metabolic process
B0009986cellular_componentcell surface
B0010467biological_processgene expression
B0010842biological_processretina layer formation
B0014004biological_processmicroglia differentiation
B0016055biological_processWnt signaling pathway
B0016358biological_processdendrite development
B0016567biological_processprotein ubiquitination
B0021554biological_processoptic nerve development
B0030182biological_processneuron differentiation
B0031290biological_processretinal ganglion cell axon guidance
B0035426biological_processextracellular matrix-cell signaling
B0035640biological_processexploration behavior
B0042803molecular_functionprotein homodimerization activity
B0045446biological_processendothelial cell differentiation
B0045893biological_processpositive regulation of DNA-templated transcription
B0046697biological_processdecidualization
B0048678biological_processresponse to axon injury
B0051402biological_processneuron apoptotic process
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0060041biological_processretina development in camera-type eye
B0060042biological_processretina morphogenesis in camera-type eye
B0060070biological_processcanonical Wnt signaling pathway
B0060221biological_processretinal rod cell differentiation
B0060856biological_processestablishment of blood-brain barrier
B0060996biological_processdendritic spine development
B0061298biological_processretina vasculature development in camera-type eye
B0061299biological_processretina vasculature morphogenesis in camera-type eye
B0061304biological_processretinal blood vessel morphogenesis
B0061518biological_processmicroglial cell proliferation
B0062023cellular_componentcollagen-containing extracellular matrix
B0070086biological_processubiquitin-dependent endocytosis
B0071456biological_processcellular response to hypoxia
B0097601biological_processretina blood vessel maintenance
B0110135biological_processNorrin signaling pathway
B1904390biological_processcone retinal bipolar cell differentiation
B1990963biological_processestablishment of blood-retinal barrier
Functional Information from PROSITE/UniProt
site_idPS01185
Number of Residues37
DetailsCTCK_1 C-terminal cystine knot signature. CCrpqtsklkalrlrCsgGmrltatyryilsChCee..C
ChainResidueDetails
ACYS95-CYS131
BCYS95-CYS131

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
CASN59
CASN144

222926

PDB entries from 2024-07-24

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