5B18

Crystal Structure of a Darunavir Resistant HIV-1 Protease

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Protease	polymer	99	10939.9	4	Pfam (PF00077) UniProt (by SIFTS) (E5RVX9)	Human immunodeficiency virus 1
2	E, F, H, I (A, B, D)	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
3	G, J (B, D)	ACETATE ION	non-polymer		59.0	2	Chemie (ACT)
4	K, L, M, N (A, B, C, D)	water	water		18.0	145	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	43759.6
Non-Polymers*	Number of molecules	6
	Total formula weight	259.9
All*	Total formula weight	44019.5

*Water molecules are not included.