5B18

Crystal Structure of a Darunavir Resistant HIV-1 Protease

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004190	molecular_function	aspartic-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0004190	molecular_function	aspartic-type endopeptidase activity
C	0006508	biological_process	proteolysis
D	0004190	molecular_function	aspartic-type endopeptidase activity
D	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CL A 101

Chain	Residue
A	GLU21
C	LYS45
C	ILE46
C	HOH104

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site_id	AC2
Number of Residues	4
Details	binding site for residue CL A 102

Chain	Residue
A	LYS45
A	ILE46
A	HOH209
C	GLU21

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site_id	AC3
Number of Residues	4
Details	binding site for residue ACT B 101

Chain	Residue
B	GLU65
B	CYS67
B	GLY68
B	THR12

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site_id	AC4
Number of Residues	5
Details	binding site for residue CL B 102

Chain	Residue
B	GLU21
B	ASN83
D	ILE46
D	HOH208
D	HOH210

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site_id	AC5
Number of Residues	4
Details	binding site for residue CL D 101

Chain	Residue
B	ILE46
D	GLU21
D	ASN83
D	HOH212

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site_id	AC6
Number of Residues	4
Details	binding site for residue ACT D 102

Chain	Residue
D	THR12
D	GLU65
D	CYS67
D	GLY68

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