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4W5R

The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8 (Long Target)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AProtein argonaute-2polymer85997378.21UniProt (Q9UKV8)
Pfam (PF16486)
Pfam (PF08699)
Pfam (PF02170)
Pfam (PF16488)
Pfam (PF16487)
Pfam (PF02171)
In PDB
Homo sapiens (Human)hAgo2,Argonaute RISC catalytic component 2,Eukaryotic translation initiation factor 2C 2,eIF2C 2,PAZ Piwi domain protein,PPD,Protein slicer
2BRNA (5'-R(P*UP*UP*CP*AP*CP*AP*UP*UP*GP*UP*U)-3')polymer216547.91synthetic construct
3DRNA (5'-R(P*AP*AP*UP*GP*UP*GP*AP*AP*A)-3')polymer134172.61synthetic construct
4AISOPROPYL ALCOHOLnon-polymer60.12Chemie (IPA)
5APHENOLnon-polymer94.13Chemie (IPH)
6A, DMAGNESIUM IONnon-polymer24.32Chemie (MG)
7waterwater18.0126Chemie (HOH)
Sequence modifications
A: 1 - 859 (UniProt: Q9UKV8)
PDBExternal DatabaseDetails
Asp 387Ser 387engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight108098.6
Non-Polymers*Number of molecules7
Total formula weight451.1
All*Total formula weight108549.8
*Water molecules are not included.

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PDB entries from 2024-09-11

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