4TOS
Crystal structure of Tankyrase 1 with 355
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tankyrase-1 | polymer | 236 | 26871.4 | 2 | UniProt (O95271) Pfam (PF00644) In PDB | Homo sapiens (Human) | TANK1,ADP-ribosyltransferase diphtheria toxin-like 5,ARTD5,Poly [ADP-ribose] polymerase 5A,TNKS-1,TRF1-interacting ankyrin-related ADP-ribose polymerase,Tankyrase I |
2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
3 | A | trans-N-benzyl-4-({1-[(6-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)methyl]-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl}methyl)cyclohexanecarboxamide | non-polymer | 563.6 | 1 | Chemie (355) | |||
4 | water | water | 18.0 | 216 | Chemie (HOH) |
Sequence modifications
A, B: 1105 - 1315 (UniProt: O95271)
PDB | External Database | Details |
---|---|---|
Met 1080 | - | initiating methionine |
Gly 1081 | - | expression tag |
Ser 1082 | - | expression tag |
Ser 1083 | - | expression tag |
His 1084 | - | expression tag |
His 1085 | - | expression tag |
His 1086 | - | expression tag |
His 1087 | - | expression tag |
His 1088 | - | expression tag |
His 1089 | - | expression tag |
Ser 1090 | - | expression tag |
Ser 1091 | - | expression tag |
Gly 1092 | - | expression tag |
Leu 1093 | - | expression tag |
Glu 1094 | - | expression tag |
Val 1095 | - | expression tag |
Leu 1096 | - | expression tag |
Phe 1097 | - | expression tag |
Gln 1098 | - | expression tag |
Gly 1099 | - | expression tag |
Pro 1100 | - | expression tag |
His 1101 | - | expression tag |
Met 1102 | - | expression tag |
Ala 1103 | - | expression tag |
Ser 1104 | - | expression tag |
Ile 1266 | Met 1266 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 53742.8 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 694.5 | |
All* | Total formula weight | 54437.2 |