4REB
Structural Insights into 5' Flap DNA Unwinding and Incision by the Human FAN1 Dimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (D) | DNA (5'-D(P*GP*TP*GP*GP*CP*GP*AP*GP*C)-3') | polymer | 9 | 2796.8 | 1 | synthetic construct | ||
| 2 | B (E) | DNA (5'-D(P*CP*GP*TP*GP*GP*CP*GP*AP*GP*CP*GP*CP*TP*CP*GP*CP*CP*AP*CP*G)-3') | polymer | 20 | 6136.9 | 1 | synthetic construct | ||
| 3 | C (F) | DNA (5'-D(P*GP*CP*TP*CP*GP*CP*CP*AP*CP*G)-3') | polymer | 10 | 3006.0 | 1 | synthetic construct | ||
| 4 | D, E (A, H) | Fanconi-associated nuclease 1 | polymer | 647 | 73653.9 | 2 | UniProt (Q9Y2M0) Pfam (PF21315) Pfam (PF21169) Pfam (PF21170) Pfam (PF08774) | Homo sapiens (human) | FANCD2/FANCI-associated nuclease 1, Myotubularin-related protein 15 |
| 5 | F, G (A, H) | SAMARIUM (III) ION | non-polymer | 150.4 | 2 | Chemie (SM) |
Sequence modifications
A, H: 373 - 1017 (UniProt: Q9Y2M0)
| PDB | External Database | Details |
|---|---|---|
| Glu 371 | - | expression tag |
| Phe 372 | - | expression tag |
| Ala 960 | Asp 960 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 159247.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 300.7 | |
| All* | Total formula weight | 159548.2 |
