4R26
Crystal structure of human Fab PGT124, a broadly neutralizing and potent HIV-1 neutralizing antibody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | L | PGR124-Light Chain | polymer | 214 | 23056.6 | 1 | UniProt (P0DOY3) Pfam (PF07654) In PDB | Nomascus leucogenys (Northern white-cheeked gibbon) | Ig lambda chain C region DOT,Ig lambda chain C region NEWM,Ig lambda-3 chain C regions |
| 2 | H | PGT124-Heavy Chain | polymer | 236 | 25460.5 | 1 | UniProt (P0DOX5) Pfam (PF07686) Pfam (PF07654) In PDB | Homo sapiens (human) | Immunoglobulin gamma-1 heavy chain NIE |
| 3 | L | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | water | water | 18.0 | 65 | Chemie (HOH) |
Sequence modifications
L: 4 - 107 (PDB: 4R26)
L: 108 - 212 (UniProt: P0DOY3)
H: 1 - 108 (PDB: 4R26)
H: 109 - 217 (UniProt: P0DOX5)
| PDB | External Database | Details |
|---|---|---|
| Ser 4 | - | expression tag |
| Tyr 5 | - | expression tag |
| Val 6 | - | expression tag |
| Ser 7 | - | expression tag |
| Leu 11 | - | conflict |
| Leu 15 | - | conflict |
| Glu 17 | - | conflict |
| Ser 22 | - | conflict |
| Arg 25 | - | conflict |
| Gln 26 | - | conflict |
| Ala 27 | - | conflict |
| Leu 28 | - | conflict |
| Ser 30 | - | conflict |
| Arg 31 | - | conflict |
| Ala 32 | - | conflict |
| Gln 34 | - | conflict |
| His 38 | - | conflict |
| Ile 45 | - | conflict |
| Leu 47 | - | conflict |
| Asn 50 | - | conflict |
| Asn 51 | - | conflict |
| Gln 52 | - | conflict |
| Asp 53 | - | conflict |
| Thr 65 | - | insertion |
| Pro 66 | - | insertion |
| Asp 66 | - | insertion |
| Ile 66 | - | conflict |
| Phe 67 | - | conflict |
| Thr 69 | - | conflict |
| Gly 77 | - | conflict |
| Val 80 | - | conflict |
| His 89 | - | conflict |
| Met 90 | - | conflict |
| Arg 94 | - | conflict |
| Gly 95 | - | conflict |
| Phe 95 | - | conflict |
| Ser 95 | - | conflict |
| Ser 97 | - | conflict |
| Ala 101 | - | conflict |
| Arg 103 | - | conflict |
| Ser 107 | - | linker |
H: 1 - 108 (PDB: 4R26)
| PDB | External Database | Details |
|---|---|---|
| Arg 13 | - | conflict |
| Val 20 | - | conflict |
| Ile 23 | - | conflict |
| Asn 31 | - | conflict |
| Thr 35 | - | conflict |
| Ser 40 | - | conflict |
| Ser 52 | - | conflict |
| Asp 53 | - | conflict |
| Arg 54 | - | conflict |
| Glu 55 | - | conflict |
| Thr 56 | - | conflict |
| Thr 58 | - | conflict |
| Asn 64 | - | conflict |
| Ala 67 | - | conflict |
| Val 68 | - | conflict |
| Arg 71 | - | conflict |
| Thr 73 | - | conflict |
| Leu 78 | - | conflict |
| Gln 81 | - | conflict |
| Arg 82 | - | conflict |
| Thr 84 | - | conflict |
| Ile 89 | - | conflict |
| Phe 91 | - | conflict |
| Thr 94 | - | insertion |
| Ala 95 | - | insertion |
| Arg 96 | - | insertion |
| Arg 97 | - | insertion |
| Gly 98 | - | insertion |
| Gln 99 | - | insertion |
| Arg 100 | - | insertion |
| Ile 100 | - | insertion |
| Tyr 100 | - | insertion |
| Gly 100 | - | conflict |
| Val 100 | - | conflict |
| Val 100 | - | conflict |
| Ser 100 | - | conflict |
| Phe 100 | - | conflict |
| Glu 100 | - | conflict |
| Phe 100 | - | conflict |
| Phe 100 | - | conflict |
| Tyr 100 | - | conflict |
| Lys 105 | - | conflict |
| Ala 108 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 48517.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 276.3 | |
| All* | Total formula weight | 48793.4 |
