4R26

Crystal structure of human Fab PGT124, a broadly neutralizing and potent HIV-1 neutralizing antibody

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0003823	molecular_function	antigen binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0016020	cellular_component	membrane
L	0016064	biological_process	immunoglobulin mediated immune response
L	0019814	cellular_component	immunoglobulin complex
L	0050853	biological_process	B cell receptor signaling pathway
L	0070062	cellular_component	extracellular exosome
L	0071735	cellular_component	IgG immunoglobulin complex
L	0071738	cellular_component	IgD immunoglobulin complex
L	0071742	cellular_component	IgE immunoglobulin complex
L	0071745	cellular_component	IgA immunoglobulin complex
L	0071753	cellular_component	IgM immunoglobulin complex
L	0072562	cellular_component	blood microparticle

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL L 301

Chain	Residue
L	GLN37
L	ILE45
L	PRO59
L	PHE62
L	GLY81
L	ASP82
L	HOH441

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL L 302

Chain	Residue
L	TYR140
L	GLY142
L	TYR172
L	THR105
L	LEU106

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL L 303

Chain	Residue
L	LEU15
L	GLY16
L	GLU17

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH

Chain	Residue	Details
L	TYR191-HIS197
H	TYR194-HIS200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:826475

Chain	Residue	Details
H	GLN1

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
H	THR73

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