4QMG

The Structure of MTDH-SND1 Complex Reveals Novel Cancer-Promoting Interactions

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G, I (A, B, C, D, E)	Staphylococcal nuclease domain-containing protein 1	polymer	325	36918.2	5	UniProt (Q7KZF4) Pfam (PF00565)	Homo sapiens (human)	100 kDa coactivator, EBNA2 coactivator p100, Tudor domain-containing protein 11, p100 co-activator
2	B, D, F, H, J (F, G, H, I, J)	Protein LYRIC	polymer	43	4392.2	5	UniProt (Q86UE4)	Homo sapiens (human)	3D3/LYRIC, Astrocyte elevated gene-1 protein, AEG-1, Lysine-rich CEACAM1 co-isolated protein, Metadherin, Metastasis adhesion protein
3	K, M, Q, S, V (A, B, C, D, E)	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
4	L, N, R, T, W (A, B, C, D, E)	CESIUM ION	non-polymer		132.9	5	Chemie (CS)
5	O, P, U, X (B, D, E)	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
6	AA, BA, CA, DA, EA... (B, C, H, D, I...)	water	water		18.0	290	Chemie (HOH)

Sequence modifications

A, B, C, D, E: 16 - 339 (UniProt: Q7KZF4)

PDB	External Database	Details
Mse 15	-	expression tag

F, G, H, I, J: 386 - 407 (UniProt: Q86UE4)

PDB	External Database	Details
Ser 365	-	expression tag
Thr 366	-	expression tag
Gly 367	-	expression tag
Asn 368	-	expression tag
Ala 369	-	expression tag
Ser 370	-	expression tag
Asp 371	-	expression tag
Ser 372	-	expression tag
Ser 373	-	expression tag
Ser 374	-	expression tag
Asp 375	-	expression tag
Ser 376	-	expression tag
Ser 377	-	expression tag
Ser 378	-	expression tag
Ser 379	-	expression tag
Glu 380	-	expression tag
Gly 381	-	expression tag
Asp 382	-	expression tag
Gly 383	-	expression tag
Thr 384	-	expression tag
Val 385	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	206552.0
Non-Polymers*	Number of molecules	14
	Total formula weight	1513.2
All*	Total formula weight	208065.2

*Water molecules are not included.