4QMG
The Structure of MTDH-SND1 Complex Reveals Novel Cancer-Promoting Interactions
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004518 | molecular_function | nuclease activity |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004518 | molecular_function | nuclease activity |
| C | 0003676 | molecular_function | nucleic acid binding |
| C | 0004518 | molecular_function | nuclease activity |
| D | 0003676 | molecular_function | nucleic acid binding |
| D | 0004518 | molecular_function | nuclease activity |
| E | 0003676 | molecular_function | nucleic acid binding |
| E | 0004518 | molecular_function | nuclease activity |
| F | 0043066 | biological_process | negative regulation of apoptotic process |
| F | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| F | 0045766 | biological_process | positive regulation of angiogenesis |
| G | 0043066 | biological_process | negative regulation of apoptotic process |
| G | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| G | 0045766 | biological_process | positive regulation of angiogenesis |
| H | 0043066 | biological_process | negative regulation of apoptotic process |
| H | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| H | 0045766 | biological_process | positive regulation of angiogenesis |
| I | 0043066 | biological_process | negative regulation of apoptotic process |
| I | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| I | 0045766 | biological_process | positive regulation of angiogenesis |
| J | 0043066 | biological_process | negative regulation of apoptotic process |
| J | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| J | 0045766 | biological_process | positive regulation of angiogenesis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 401 |
| Chain | Residue |
| A | SER170 |
| A | HIS171 |
| A | ILE173 |
| A | ASP175 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS A 402 |
| Chain | Residue |
| A | MSE163 |
| A | SER165 |
| A | GLY167 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 401 |
| Chain | Residue |
| B | ARG174 |
| B | GLU200 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS B 402 |
| Chain | Residue |
| B | MSE163 |
| B | SER165 |
| B | GLY167 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 403 |
| Chain | Residue |
| B | HIS201 |
| B | ARG203 |
| B | ARG209 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 404 |
| Chain | Residue |
| B | HIS201 |
| B | VAL202 |
| B | LYS249 |
| B | GLU253 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 401 |
| Chain | Residue |
| C | ARG83 |
| C | ARG174 |
| C | GLU200 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS C 402 |
| Chain | Residue |
| C | MSE163 |
| C | SER165 |
| C | GLY167 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 401 |
| Chain | Residue |
| D | ARG83 |
| D | ARG174 |
| D | GLU200 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS D 402 |
| Chain | Residue |
| D | MSE163 |
| D | SER165 |
| D | GLY167 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL D 403 |
| Chain | Residue |
| D | HIS201 |
| D | ARG203 |
| D | ARG209 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 E 401 |
| Chain | Residue |
| E | LEU59 |
| E | ALA60 |
| E | ARG83 |
| E | ARG174 |
| E | GLU200 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CS E 402 |
| Chain | Residue |
| E | MSE163 |
| E | SER165 |
| E | GLY167 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL E 403 |
| Chain | Residue |
| E | HIS201 |
| E | ARG203 |
| E | ARG209 |
Functional Information from PROSITE/UniProt
| site_id | PS01284 |
| Number of Residues | 11 |
| Details | TNASE_2 Thermonuclease family signature 2. TPQGReYGmIY |
| Chain | Residue | Details |
| A | THR103-TYR113 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | THR103 | |
| E | THR240 | |
| A | THR240 | |
| B | THR103 | |
| B | THR240 | |
| C | THR103 | |
| C | THR240 | |
| D | THR103 | |
| D | THR240 | |
| E | THR103 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS193 | |
| B | LYS193 | |
| C | LYS193 | |
| D | LYS193 | |
| E | LYS193 |
