4Q9U

Crystal structure of the Rab5, Rabex-5delta and Rabaptin-5C21 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (A, E)	Rab5 GDP/GTP exchange factor	polymer	317	37320.9	2	UniProt (Q9UJ41) Pfam (PF18151) Pfam (PF02204)	Homo sapiens (human)	Rabex-5delta, RAP1, Rabaptin-5-associated exchange factor for Rab5, Rabex-5
2	B, F (B, F)	Ras-related protein Rab-5A	polymer	171	19074.6	2	UniProt (P20339) Pfam (PF00071)	Homo sapiens (human)	Rabaptin-5C21
3	C, D, G, H (C, D, G, H)	Rab GTPase-binding effector protein 1	polymer	92	10701.1	4	UniProt (Q15276)	Homo sapiens (human)	Rab5, Rabaptin-4, Rabaptin-5, Rabaptin-5alpha, Renal carcinoma antigen NY-REN-17

Sequence modifications

A, E: 132 - 440 (UniProt: Q9UJ41)

PDB	External Database	Details
Met 124	-	expression tag
Gly 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag
His 128	-	expression tag
His 129	-	expression tag
His 130	-	expression tag
His 131	-	expression tag
-	Lys 393	deletion
-	Gln 394	deletion
-	Glu 395	deletion
-	Ala 396	deletion
-	Glu 397	deletion
-	Ser 398	deletion
-	Trp 399	deletion
-	Ser 400	deletion
-	Pro 401	deletion
-	Asp 402	deletion
-	Ala 403	deletion
-	Cys 404	deletion
-	Leu 405	deletion
-	Gly 406	deletion
-	Val 407	deletion

B, F: 15 - 184 (UniProt: P20339)

PDB	External Database	Details
Ser 14	-	expression tag

C, D, G, H: 552 - 642 (UniProt: Q15276)

PDB	External Database	Details
Met 551	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	155595.4
All*	Total formula weight	155595.4

*Water molecules are not included.