4Q9U
Crystal structure of the Rab5, Rabex-5delta and Rabaptin-5C21 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| A | 0016192 | biological_process | vesicle-mediated transport |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| C | 0005096 | molecular_function | GTPase activator activity |
| C | 0006897 | biological_process | endocytosis |
| D | 0005096 | molecular_function | GTPase activator activity |
| D | 0006897 | biological_process | endocytosis |
| E | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| E | 0016192 | biological_process | vesicle-mediated transport |
| F | 0003924 | molecular_function | GTPase activity |
| F | 0005525 | molecular_function | GTP binding |
| G | 0005096 | molecular_function | GTPase activator activity |
| G | 0006897 | biological_process | endocytosis |
| H | 0005096 | molecular_function | GTPase activator activity |
| H | 0006897 | biological_process | endocytosis |
Functional Information from PROSITE/UniProt
| site_id | PS00014 |
| Number of Residues | 4 |
| Details | ER_TARGET Endoplasmic reticulum targeting sequence. SEEL |
| Chain | Residue | Details |
| C | SER639-LEU642 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12433916, ECO:0000269|PubMed:14684892, ECO:0000269|PubMed:15378032, ECO:0000269|PubMed:20534488, ECO:0007744|PDB:1N6H, ECO:0007744|PDB:1N6L, ECO:0007744|PDB:1N6N, ECO:0007744|PDB:1N6O, ECO:0007744|PDB:1N6P, ECO:0007744|PDB:1N6R, ECO:0007744|PDB:1R2Q, ECO:0007744|PDB:1TU3, ECO:0007744|PDB:3MJH |
| Chain | Residue | Details |
| B | GLY27 | |
| F | SER163 | |
| B | HIS46 | |
| B | ASP75 | |
| B | ASN133 | |
| B | SER163 | |
| F | GLY27 | |
| F | HIS46 | |
| F | ASP75 | |
| F | ASN133 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by LRRK2 => ECO:0000269|PubMed:29125462 |
| Chain | Residue | Details |
| B | SER84 | |
| F | SER84 | |
| E | LYS151 | |
| E | LYS170 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CARBOHYD: (Microbial infection) N-beta-linked (GlcNAc) arginine => ECO:0000269|PubMed:32974215 |
| Chain | Residue | Details |
| B | ARG120 | |
| F | ARG120 | |
| E | SER373 | |
| E | SER377 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9JM13 |
| Chain | Residue | Details |
| A | SER390 | |
| E | SER390 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | ASP400 | |
| E | ASP400 |
