4O6Z

Crystal structure of serine hydroxymethyltransferase with covalently bound PLP Schiff-base from Plasmodium falciparum

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Serine hydroxymethyltransferase	polymer	480	54116.5	4	UniProt (Q8I566) Pfam (PF00464)	Plasmodium falciparum
2	E, F, G (A, B, C)	PYRIDOXAL-5'-PHOSPHATE	non-polymer		247.1	3	Chemie (PLP) PubChem (1051)
3	H (D)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4) PubChem (1061)
4	I, J, K, L (A, B, C, D)	water	water		18.0	138	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 442 (UniProt: Q8I566)

PDB	External Database	Details
Met -37	-	expression tag
Arg -36	-	expression tag
Gly -35	-	expression tag
Ser -34	-	expression tag
His -33	-	expression tag
His -32	-	expression tag
His -31	-	expression tag
His -30	-	expression tag
His -29	-	expression tag
His -28	-	expression tag
Gly -27	-	expression tag
Met -26	-	expression tag
Ala -25	-	expression tag
Ser -24	-	expression tag
Met -23	-	expression tag
Thr -22	-	expression tag
Gly -21	-	expression tag
Gly -20	-	expression tag
Gln -19	-	expression tag
Gln -18	-	expression tag
Met -17	-	expression tag
Gly -16	-	expression tag
Arg -15	-	expression tag
Asp -14	-	expression tag
Leu -13	-	expression tag
Tyr -12	-	expression tag
Asp -11	-	expression tag
Asp -10	-	expression tag
Asp -9	-	expression tag
Asp -8	-	expression tag
Lys -7	-	expression tag
Asp -6	-	expression tag
His -5	-	expression tag
Pro -4	-	expression tag
Phe -3	-	expression tag
Thr -2	-	expression tag
Pro -1	-	expression tag
Gly 0	-	expression tag
Glu 292	Phe 292	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	216466.1
Non-Polymers*	Number of molecules	4
	Total formula weight	836.4
All*	Total formula weight	217302.5

*Water molecules are not included.