4O6Z

Crystal structure of serine hydroxymethyltransferase with covalently bound PLP Schiff-base from Plasmodium falciparum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004372	molecular_function	glycine hydroxymethyltransferase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006730	biological_process	one-carbon metabolic process
A	0019264	biological_process	glycine biosynthetic process from L-serine
A	0020011	cellular_component	apicoplast
A	0030170	molecular_function	pyridoxal phosphate binding
A	0035999	biological_process	tetrahydrofolate interconversion
A	0042803	molecular_function	protein homodimerization activity
A	0046653	biological_process	tetrahydrofolate metabolic process
A	0070178	biological_process	D-serine metabolic process
B	0004372	molecular_function	glycine hydroxymethyltransferase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006730	biological_process	one-carbon metabolic process
B	0019264	biological_process	glycine biosynthetic process from L-serine
B	0020011	cellular_component	apicoplast
B	0030170	molecular_function	pyridoxal phosphate binding
B	0035999	biological_process	tetrahydrofolate interconversion
B	0042803	molecular_function	protein homodimerization activity
B	0046653	biological_process	tetrahydrofolate metabolic process
B	0070178	biological_process	D-serine metabolic process
C	0004372	molecular_function	glycine hydroxymethyltransferase activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006730	biological_process	one-carbon metabolic process
C	0019264	biological_process	glycine biosynthetic process from L-serine
C	0020011	cellular_component	apicoplast
C	0030170	molecular_function	pyridoxal phosphate binding
C	0035999	biological_process	tetrahydrofolate interconversion
C	0042803	molecular_function	protein homodimerization activity
C	0046653	biological_process	tetrahydrofolate metabolic process
C	0070178	biological_process	D-serine metabolic process
D	0004372	molecular_function	glycine hydroxymethyltransferase activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006730	biological_process	one-carbon metabolic process
D	0019264	biological_process	glycine biosynthetic process from L-serine
D	0020011	cellular_component	apicoplast
D	0030170	molecular_function	pyridoxal phosphate binding
D	0035999	biological_process	tetrahydrofolate interconversion
D	0042803	molecular_function	protein homodimerization activity
D	0046653	biological_process	tetrahydrofolate metabolic process
D	0070178	biological_process	D-serine metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PLP A 701

Chain	Residue
A	SER100
A	LYS237
A	HOH832
B	TYR54
B	GLY272
A	GLY101
A	SER102
A	HIS129
A	ASP208
A	SER210
A	HIS211
A	THR234
A	HIS236

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PLP B 701

Chain	Residue
A	TYR54
A	GLY272
B	SER100
B	GLY101
B	SER102
B	HIS129
B	THR183
B	ASP208
B	SER210
B	HIS211
B	THR234
B	HIS236
B	LYS237
B	HOH832

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PLP C 701

Chain	Residue
C	SER100
C	GLY101
C	SER102
C	HIS129
C	THR183
C	ASP208
C	SER210
C	HIS211
C	THR234
C	HIS236
C	LYS237
D	TYR54
D	GLY271
D	GLY272

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 D 501

Chain	Residue
C	TYR54
C	GLY271
C	GLY272
D	SER100
D	GLY101
D	SER102
D	THR234

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24914963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4O6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"24914963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4O6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"PIRSR","id":"PIRSR000412-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24914963","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4O6Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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