4MQW

Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G	Glycoprotein hormones, alpha polypeptide	polymer	102	11364.0	3	UniProt (Q96QJ4) Pfam (PF00236) UniProt (by SIFTS) (P01215) In PDB	Homo sapiens (human)
2	B, E, H	Follitropin subunit beta	polymer	111	12500.2	3	UniProt (P01225) Pfam (PF00007) In PDB	Homo sapiens (human)	Follicle-stimulating hormone beta subunit, FSH-B, FSH-beta, Follitropin beta chain
3	X, Y, Z	Follicle-stimulating hormone receptor	polymer	361	41332.7	3	UniProt (P23945) Pfam (PF01462) Pfam (PF13306) Pfam (PF12369) In PDB	Homo sapiens (human)	FSH-R, Follitropin receptor
4	H, Z, A, B, X...	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	15	Chemie (NAG)
5	B, X, Y	1,2-ETHANEDIOL	non-polymer		62.1	5	Chemie (EDO)
6	Z	O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500)	non-polymer		597.8	1	Chemie (JEF)
7		water	water		18.0	155	Chemie (HOH)

Sequence modifications

A, D, G: 1 - 92 (UniProt: Q96QJ4)

PDB	External Database	Details
Ala 93	-	expression tag
Ala 94	-	expression tag
Ala 95	-	expression tag
His 96	-	expression tag
His 97	-	expression tag
His 98	-	expression tag
His 99	-	expression tag
His 100	-	expression tag
His 101	-	expression tag
His 102	-	expression tag

X, Y, Z: 16 - 366 (UniProt: P23945)

PDB	External Database	Details
Ser 188	Cys 188	engineered mutation
Ala 367	-	expression tag
Ala 368	-	expression tag
Ala 369	-	expression tag
His 370	-	expression tag
His 371	-	expression tag
His 372	-	expression tag
His 373	-	expression tag
His 374	-	expression tag
His 375	-	expression tag
His 376	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	195590.9
Non-Polymers*	Number of molecules	21
	Total formula weight	4226.3
All*	Total formula weight	199817.1

*Water molecules are not included.