4MQW
Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G (A, D, G) | Glycoprotein hormones, alpha polypeptide | polymer | 102 | 11364.0 | 3 | UniProt (Q96QJ4) Pfam (PF00236) UniProt (by SIFTS) (P01215) | Homo sapiens (human) | |
| 2 | B, E, H (B, E, H) | Follitropin subunit beta | polymer | 111 | 12500.2 | 3 | UniProt (P01225) Pfam (PF00007) | Homo sapiens (human) | Follicle-stimulating hormone beta subunit, FSH-B, FSH-beta, Follitropin beta chain |
| 3 | C, F, I (X, Y, Z) | Follicle-stimulating hormone receptor | polymer | 361 | 41332.7 | 3 | UniProt (P23945) Pfam (PF01462) Pfam (PF13306) Pfam (PF12369) | Homo sapiens (human) | FSH-R, Follitropin receptor |
| 4 | AA, BA, DA, J, K... (H, Z, A, B, X...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 15 | Chemie (NAG) | |||
| 5 | N, O, P, Q, W (B, X, Y) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 6 | CA (Z) | O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500) | non-polymer | 597.8 | 1 | Chemie (JEF) | |||
| 7 | EA, FA, GA, HA, IA... (A, B, X, D, E...) | water | water | 18.0 | 155 | Chemie (HOH) |
Sequence modifications
A, D, G: 1 - 92 (UniProt: Q96QJ4)
X, Y, Z: 16 - 366 (UniProt: P23945)
| PDB | External Database | Details |
|---|---|---|
| Ala 93 | - | expression tag |
| Ala 94 | - | expression tag |
| Ala 95 | - | expression tag |
| His 96 | - | expression tag |
| His 97 | - | expression tag |
| His 98 | - | expression tag |
| His 99 | - | expression tag |
| His 100 | - | expression tag |
| His 101 | - | expression tag |
| His 102 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 188 | Cys 188 | engineered mutation |
| Ala 367 | - | expression tag |
| Ala 368 | - | expression tag |
| Ala 369 | - | expression tag |
| His 370 | - | expression tag |
| His 371 | - | expression tag |
| His 372 | - | expression tag |
| His 373 | - | expression tag |
| His 374 | - | expression tag |
| His 375 | - | expression tag |
| His 376 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 195590.9 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 4226.3 | |
| All* | Total formula weight | 199817.1 |
