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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4MQW

Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31)

Functional Information from GO Data
ChainGOidnamespacecontents
A0005179molecular_functionhormone activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005796cellular_componentGolgi lumen
A0007186biological_processG protein-coupled receptor signaling pathway
A0008284biological_processpositive regulation of cell population proliferation
A0009755biological_processhormone-mediated signaling pathway
A0010469biological_processregulation of signaling receptor activity
A0010893biological_processpositive regulation of steroid biosynthetic process
A0016913molecular_functionfollicle-stimulating hormone activity
A0016914cellular_componentfollicle-stimulating hormone complex
A0030335biological_processpositive regulation of cell migration
A0042699biological_processfollicle-stimulating hormone signaling pathway
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0061696cellular_componentpituitary gonadotropin complex
B0001541biological_processovarian follicle development
B0005102molecular_functionsignaling receptor binding
B0005179molecular_functionhormone activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0006701biological_processprogesterone biosynthetic process
B0007165biological_processsignal transduction
B0007179biological_processtransforming growth factor beta receptor signaling pathway
B0007186biological_processG protein-coupled receptor signaling pathway
B0007292biological_processfemale gamete generation
B0007565biological_processfemale pregnancy
B0008284biological_processpositive regulation of cell population proliferation
B0010893biological_processpositive regulation of steroid biosynthetic process
B0016913molecular_functionfollicle-stimulating hormone activity
B0016914cellular_componentfollicle-stimulating hormone complex
B0030335biological_processpositive regulation of cell migration
B0042699biological_processfollicle-stimulating hormone signaling pathway
B0045944biological_processpositive regulation of transcription by RNA polymerase II
D0005179molecular_functionhormone activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005796cellular_componentGolgi lumen
D0007186biological_processG protein-coupled receptor signaling pathway
D0008284biological_processpositive regulation of cell population proliferation
D0009755biological_processhormone-mediated signaling pathway
D0010469biological_processregulation of signaling receptor activity
D0010893biological_processpositive regulation of steroid biosynthetic process
D0016913molecular_functionfollicle-stimulating hormone activity
D0016914cellular_componentfollicle-stimulating hormone complex
D0030335biological_processpositive regulation of cell migration
D0042699biological_processfollicle-stimulating hormone signaling pathway
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0061696cellular_componentpituitary gonadotropin complex
E0001541biological_processovarian follicle development
E0005102molecular_functionsignaling receptor binding
E0005179molecular_functionhormone activity
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0005737cellular_componentcytoplasm
E0006701biological_processprogesterone biosynthetic process
E0007165biological_processsignal transduction
E0007179biological_processtransforming growth factor beta receptor signaling pathway
E0007186biological_processG protein-coupled receptor signaling pathway
E0007292biological_processfemale gamete generation
E0007565biological_processfemale pregnancy
E0008284biological_processpositive regulation of cell population proliferation
E0010893biological_processpositive regulation of steroid biosynthetic process
E0016913molecular_functionfollicle-stimulating hormone activity
E0016914cellular_componentfollicle-stimulating hormone complex
E0030335biological_processpositive regulation of cell migration
E0042699biological_processfollicle-stimulating hormone signaling pathway
E0045944biological_processpositive regulation of transcription by RNA polymerase II
G0005179molecular_functionhormone activity
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005796cellular_componentGolgi lumen
G0007186biological_processG protein-coupled receptor signaling pathway
G0008284biological_processpositive regulation of cell population proliferation
G0009755biological_processhormone-mediated signaling pathway
G0010469biological_processregulation of signaling receptor activity
G0010893biological_processpositive regulation of steroid biosynthetic process
G0016913molecular_functionfollicle-stimulating hormone activity
G0016914cellular_componentfollicle-stimulating hormone complex
G0030335biological_processpositive regulation of cell migration
G0042699biological_processfollicle-stimulating hormone signaling pathway
G0045944biological_processpositive regulation of transcription by RNA polymerase II
G0061696cellular_componentpituitary gonadotropin complex
H0001541biological_processovarian follicle development
H0005102molecular_functionsignaling receptor binding
H0005179molecular_functionhormone activity
H0005515molecular_functionprotein binding
H0005576cellular_componentextracellular region
H0005615cellular_componentextracellular space
H0005737cellular_componentcytoplasm
H0006701biological_processprogesterone biosynthetic process
H0007165biological_processsignal transduction
H0007179biological_processtransforming growth factor beta receptor signaling pathway
H0007186biological_processG protein-coupled receptor signaling pathway
H0007292biological_processfemale gamete generation
H0007565biological_processfemale pregnancy
H0008284biological_processpositive regulation of cell population proliferation
H0010893biological_processpositive regulation of steroid biosynthetic process
H0016913molecular_functionfollicle-stimulating hormone activity
H0016914cellular_componentfollicle-stimulating hormone complex
H0030335biological_processpositive regulation of cell migration
H0042699biological_processfollicle-stimulating hormone signaling pathway
H0045944biological_processpositive regulation of transcription by RNA polymerase II
X0004963molecular_functionfollicle-stimulating hormone receptor activity
X0007186biological_processG protein-coupled receptor signaling pathway
X0016020cellular_componentmembrane
Y0004963molecular_functionfollicle-stimulating hormone receptor activity
Y0007186biological_processG protein-coupled receptor signaling pathway
Y0016020cellular_componentmembrane
Z0004963molecular_functionfollicle-stimulating hormone receptor activity
Z0007186biological_processG protein-coupled receptor signaling pathway
Z0016020cellular_componentmembrane
Functional Information from PROSITE/UniProt
site_idPS00261
Number of Residues7
DetailsGLYCO_HORMONE_BETA_1 Glycoprotein hormones beta chain signature 1. CAGYCyT
ChainResidueDetails
BCYS28-THR34
site_idPS00689
Number of Residues28
DetailsGLYCO_HORMONE_BETA_2 Glycoprotein hormones beta chain signature 2. PVAtqChCgkCdsdsTDCtvrglg..PsyC
ChainResidueDetails
BPRO77-CYS104
site_idPS00779
Number of Residues13
DetailsGLYCO_HORMONE_ALPHA_1 Glycoprotein hormones alpha chain signature 1. CmGCCFSRAYPTP
ChainResidueDetails
ACYS28-PRO40
site_idPS00780
Number of Residues14
DetailsGLYCO_HORMONE_ALPHA_2 Glycoprotein hormones alpha chain signature 2. NHTaChCsTCyyHK
ChainResidueDetails
AASN78-LYS91
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000036","evidences":[{"source":"PubMed","id":"15662415","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24692546","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MQW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","featureId":"CAR_000037","evidences":[{"source":"PubMed","id":"15662415","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24692546","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MQW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15662415","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"4835136","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MQW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues84
DetailsDomain: {"description":"LRRNT"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues69
DetailsRepeat: {"description":"LRR 1"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues72
DetailsRepeat: {"description":"LRR 2"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues60
DetailsRepeat: {"description":"LRR 3"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues72
DetailsRepeat: {"description":"LRR 4"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues75
DetailsRepeat: {"description":"LRR 5"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues66
DetailsRepeat: {"description":"LRR 6"}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues69
DetailsRepeat: {"description":"LRR 7"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues69
DetailsRepeat: {"description":"LRR 8"}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues54
DetailsRepeat: {"description":"LRR 9"}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues3
DetailsModified residue: {"description":"Sulfotyrosine","evidences":[{"source":"PubMed","id":"11847099","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15662415","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24692546","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4MQW","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2025-12-03

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