Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4MQW

Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005796	cellular_component	Golgi lumen
A	0006590	biological_process	thyroid hormone generation
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008406	biological_process	gonad development
A	0009755	biological_process	hormone-mediated signaling pathway
A	0010469	biological_process	regulation of signaling receptor activity
A	0010893	biological_process	positive regulation of steroid biosynthetic process
A	0016913	molecular_function	follicle-stimulating hormone activity
A	0016914	cellular_component	follicle-stimulating hormone complex
A	0030335	biological_process	positive regulation of cell migration
A	0030878	biological_process	thyroid gland development
A	0032275	biological_process	luteinizing hormone secretion
A	0032870	biological_process	cellular response to hormone stimulus
A	0035265	biological_process	organ growth
A	0042699	biological_process	follicle-stimulating hormone signaling pathway
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046621	biological_process	negative regulation of organ growth
A	0046884	biological_process	follicle-stimulating hormone secretion
A	0048589	biological_process	developmental growth
A	0061696	cellular_component	pituitary gonadotropin complex
B	0001541	biological_process	ovarian follicle development
B	0005179	molecular_function	hormone activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0006701	biological_process	progesterone biosynthetic process
B	0007179	biological_process	transforming growth factor beta receptor signaling pathway
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007283	biological_process	spermatogenesis
B	0007292	biological_process	female gamete generation
B	0007565	biological_process	female pregnancy
B	0008284	biological_process	positive regulation of cell population proliferation
B	0010469	biological_process	regulation of signaling receptor activity
B	0010628	biological_process	positive regulation of gene expression
B	0010893	biological_process	positive regulation of steroid biosynthetic process
B	0016913	molecular_function	follicle-stimulating hormone activity
B	0016914	cellular_component	follicle-stimulating hormone complex
B	0030335	biological_process	positive regulation of cell migration
B	0042699	biological_process	follicle-stimulating hormone signaling pathway
B	0045670	biological_process	regulation of osteoclast differentiation
B	0045780	biological_process	positive regulation of bone resorption
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0060011	biological_process	Sertoli cell proliferation
D	0005179	molecular_function	hormone activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005796	cellular_component	Golgi lumen
D	0006590	biological_process	thyroid hormone generation
D	0007186	biological_process	G protein-coupled receptor signaling pathway
D	0008284	biological_process	positive regulation of cell population proliferation
D	0008406	biological_process	gonad development
D	0009755	biological_process	hormone-mediated signaling pathway
D	0010469	biological_process	regulation of signaling receptor activity
D	0010893	biological_process	positive regulation of steroid biosynthetic process
D	0016913	molecular_function	follicle-stimulating hormone activity
D	0016914	cellular_component	follicle-stimulating hormone complex
D	0030335	biological_process	positive regulation of cell migration
D	0030878	biological_process	thyroid gland development
D	0032275	biological_process	luteinizing hormone secretion
D	0032870	biological_process	cellular response to hormone stimulus
D	0035265	biological_process	organ growth
D	0042699	biological_process	follicle-stimulating hormone signaling pathway
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046621	biological_process	negative regulation of organ growth
D	0046884	biological_process	follicle-stimulating hormone secretion
D	0048589	biological_process	developmental growth
D	0061696	cellular_component	pituitary gonadotropin complex
E	0001541	biological_process	ovarian follicle development
E	0005179	molecular_function	hormone activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0006701	biological_process	progesterone biosynthetic process
E	0007179	biological_process	transforming growth factor beta receptor signaling pathway
E	0007186	biological_process	G protein-coupled receptor signaling pathway
E	0007283	biological_process	spermatogenesis
E	0007292	biological_process	female gamete generation
E	0007565	biological_process	female pregnancy
E	0008284	biological_process	positive regulation of cell population proliferation
E	0010469	biological_process	regulation of signaling receptor activity
E	0010628	biological_process	positive regulation of gene expression
E	0010893	biological_process	positive regulation of steroid biosynthetic process
E	0016913	molecular_function	follicle-stimulating hormone activity
E	0016914	cellular_component	follicle-stimulating hormone complex
E	0030335	biological_process	positive regulation of cell migration
E	0042699	biological_process	follicle-stimulating hormone signaling pathway
E	0045670	biological_process	regulation of osteoclast differentiation
E	0045780	biological_process	positive regulation of bone resorption
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0060011	biological_process	Sertoli cell proliferation
G	0005179	molecular_function	hormone activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005796	cellular_component	Golgi lumen
G	0006590	biological_process	thyroid hormone generation
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0008284	biological_process	positive regulation of cell population proliferation
G	0008406	biological_process	gonad development
G	0009755	biological_process	hormone-mediated signaling pathway
G	0010469	biological_process	regulation of signaling receptor activity
G	0010893	biological_process	positive regulation of steroid biosynthetic process
G	0016913	molecular_function	follicle-stimulating hormone activity
G	0016914	cellular_component	follicle-stimulating hormone complex
G	0030335	biological_process	positive regulation of cell migration
G	0030878	biological_process	thyroid gland development
G	0032275	biological_process	luteinizing hormone secretion
G	0032870	biological_process	cellular response to hormone stimulus
G	0035265	biological_process	organ growth
G	0042699	biological_process	follicle-stimulating hormone signaling pathway
G	0045944	biological_process	positive regulation of transcription by RNA polymerase II
G	0046621	biological_process	negative regulation of organ growth
G	0046884	biological_process	follicle-stimulating hormone secretion
G	0048589	biological_process	developmental growth
G	0061696	cellular_component	pituitary gonadotropin complex
H	0001541	biological_process	ovarian follicle development
H	0005179	molecular_function	hormone activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005737	cellular_component	cytoplasm
H	0006701	biological_process	progesterone biosynthetic process
H	0007179	biological_process	transforming growth factor beta receptor signaling pathway
H	0007186	biological_process	G protein-coupled receptor signaling pathway
H	0007283	biological_process	spermatogenesis
H	0007292	biological_process	female gamete generation
H	0007565	biological_process	female pregnancy
H	0008284	biological_process	positive regulation of cell population proliferation
H	0010469	biological_process	regulation of signaling receptor activity
H	0010628	biological_process	positive regulation of gene expression
H	0010893	biological_process	positive regulation of steroid biosynthetic process
H	0016913	molecular_function	follicle-stimulating hormone activity
H	0016914	cellular_component	follicle-stimulating hormone complex
H	0030335	biological_process	positive regulation of cell migration
H	0042699	biological_process	follicle-stimulating hormone signaling pathway
H	0045670	biological_process	regulation of osteoclast differentiation
H	0045780	biological_process	positive regulation of bone resorption
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0060011	biological_process	Sertoli cell proliferation
X	0004963	molecular_function	follicle-stimulating hormone receptor activity
X	0007186	biological_process	G protein-coupled receptor signaling pathway
X	0016020	cellular_component	membrane
Y	0004963	molecular_function	follicle-stimulating hormone receptor activity
Y	0007186	biological_process	G protein-coupled receptor signaling pathway
Y	0016020	cellular_component	membrane
Z	0004963	molecular_function	follicle-stimulating hormone receptor activity
Z	0007186	biological_process	G protein-coupled receptor signaling pathway
Z	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00261
Number of Residues	7
Details	GLYCO_HORMONE_BETA_1 Glycoprotein hormones beta chain signature 1. CAGYCyT

Chain	Residue	Details
B	CYS28-THR34

site_id	PS00689
Number of Residues	28
Details	GLYCO_HORMONE_BETA_2 Glycoprotein hormones beta chain signature 2. PVAtqChCgkCdsdsTDCtvrglg..PsyC

Chain	Residue	Details
B	PRO77-CYS104

site_id	PS00779
Number of Residues	13
Details	GLYCO_HORMONE_ALPHA_1 Glycoprotein hormones alpha chain signature 1. CmGCCFSRAYPTP

Chain	Residue	Details
A	CYS28-PRO40

site_id	PS00780
Number of Residues	14
Details	GLYCO_HORMONE_ALPHA_2 Glycoprotein hormones alpha chain signature 2. NHTaChCsTCyyHK

Chain	Residue	Details
A	ASN78-LYS91

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:15662415, ECO:0000269\|PubMed:24692546, ECO:0007744\|PDB:4MQW

Chain	Residue	Details
A	ASN52
A	ASN78
D	ASN52
D	ASN78
G	ASN52
G	ASN78

site_id	SWS_FT_FI2
Number of Residues	3
Details	MOD_RES: Sulfotyrosine => ECO:0000305\|PubMed:11847099

Chain	Residue	Details
X	TYS335
Y	TYS335
Z	TYS335

site_id	SWS_FT_FI3
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:15662415, ECO:0000269\|PubMed:24692546, ECO:0007744\|PDB:4MQW

Chain	Residue	Details
X	ASN191
Y	ASN191
Z	ASN191

site_id	SWS_FT_FI4
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
X	ASN199
X	ASN318
Y	ASN199
Y	ASN318
Z	ASN199
Z	ASN318

site_id	SWS_FT_FI5
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000250

Chain	Residue	Details
X	ASN293
Y	ASN293
Z	ASN293

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)