4LGY

Importance of Hydrophobic Cavities in Allosteric Regulation of Formylglycinamide Synthetase: Insight from Xenon Trapping and Statistical Coupling Analysis

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Phosphoribosylformylglycinamidine synthase	polymer	1305	142777.6	1	UniProt (P74881) Pfam (PF18076) Pfam (PF18072) Pfam (PF02769) Pfam (PF13507) In PDB	Salmonella typhimurium	FGAM synthase, FGAMS, Formylglycinamide ribotide amidotransferase, FGARAT, Formylglycinamide ribotide synthetase
2	A	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
3	A	MAGNESIUM ION	non-polymer		24.3	7	Chemie (MG)
4	A	SULFATE ION	non-polymer		96.1	19	Chemie (SO4)
5	A	ACETATE ION	non-polymer		59.0	3	Chemie (ACT)
6	A	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
7	A	CHLORIDE ION	non-polymer		35.5	6	Chemie (CL)
8		water	water		18.0	1610	Chemie (HOH)

Sequence modifications

A: 1 - 1295 (UniProt: P74881)

PDB	External Database	Details
Gly -9	-	expression tag
Asp -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Trp 209	Phe 209	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	142777.6
Non-Polymers*	Number of molecules	40
	Total formula weight	3180.8
All*	Total formula weight	145958.4

*Water molecules are not included.