4LGY
Importance of Hydrophobic Cavities in Allosteric Regulation of Formylglycinamide Synthetase: Insight from Xenon Trapping and Statistical Coupling Analysis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phosphoribosylformylglycinamidine synthase | polymer | 1305 | 142777.6 | 1 | UniProt (P74881) Pfam (PF18076) Pfam (PF18072) Pfam (PF02769) Pfam (PF22689) Pfam (PF13507) | Salmonella typhimurium | FGAM synthase, FGAMS, Formylglycinamide ribotide amidotransferase, FGARAT, Formylglycinamide ribotide synthetase |
| 2 | B (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 3 | C, D, E, LA, MA... (A) | MAGNESIUM ION | non-polymer | 24.3 | 7 | Chemie (MG) | |||
| 4 | F, G, H, I, J... (A) | SULFATE ION | non-polymer | 96.1 | 19 | Chemie (SO4) | |||
| 5 | AA, Y, Z (A) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 6 | BA, CA, DA, EA (A) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 7 | FA, GA, HA, IA, JA... (A) | CHLORIDE ION | non-polymer | 35.5 | 6 | Chemie (CL) | |||
| 8 | PA (A) | water | water | 18.0 | 1610 | Chemie (HOH) |
Sequence modifications
A: 1 - 1295 (UniProt: P74881)
| PDB | External Database | Details |
|---|---|---|
| Gly -9 | - | expression tag |
| Asp -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Arg -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
| Trp 209 | Phe 209 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 142777.6 | |
| Non-Polymers* | Number of molecules | 40 |
| Total formula weight | 3180.8 | |
| All* | Total formula weight | 145958.4 |
