Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4LGY

Importance of Hydrophobic Cavities in Allosteric Regulation of Formylglycinamide Synthetase: Insight from Xenon Trapping and Statistical Coupling Analysis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004642	molecular_function	phosphoribosylformylglycinamidine synthase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	33
Details	BINDING SITE FOR RESIDUE ADP A 1301

Chain	Residue
A	VAL333
A	PRO676
A	ALA678
A	ASP679
A	GLU718
A	ASN722
A	SER886
A	MG1302
A	MG1303
A	MG1304
A	HOH1404
A	THR386
A	HOH1420
A	HOH1428
A	HOH1430
A	HOH1488
A	HOH1567
A	HOH1568
A	HOH1742
A	HOH1751
A	HOH2421
A	HOH2423
A	GLY387
A	HOH2424
A	HOH2425
A	HOH2426
A	HOH2427
A	TYR388
A	PHE389
A	LYS649
A	LEU652
A	VAL653
A	GLN668

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1302

Chain	Residue
A	ASP679
A	ASN722
A	ASP884
A	ADP1301
A	HOH2423
A	HOH2425

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1303

Chain	Residue
A	GLU718
A	ADP1301
A	HOH1420
A	HOH2422
A	HOH2424
A	HOH2427

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1304

Chain	Residue
A	ADP1301
A	HOH1404
A	HOH1428
A	HOH2421
A	HOH2426

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1305

Chain	Residue
A	HIS216
A	GLY504
A	ALA505
A	LYS776
A	HOH2093

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 A 1306

Chain	Residue
A	HIS216
A	THR295
A	HIS296
A	ASN297
A	HIS298
A	SER778
A	HOH1692
A	HOH1817
A	HOH2004
A	HOH2786
A	HOH2821

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 1307

Chain	Residue
A	TYR690
A	ARG812
A	LYS1228
A	VAL1229
A	HOH1553
A	HOH1813
A	HOH1962
A	HOH2338
A	HOH2829

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1308

Chain	Residue
A	PRO356
A	GLU357
A	ARG358
A	HOH2057
A	HOH2091
A	HOH2140

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 1309

Chain	Residue
A	PRO1040
A	LYS1041
A	HIS1086
A	HOH1635
A	HOH2067
A	HOH2431
A	HOH2508
A	HOH2550

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1310

Chain	Residue
A	LYS833
A	HIS835
A	ARG858
A	HOH1865
A	HOH2165
A	HOH2525

site_id	BC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 1311

Chain	Residue
A	HOH1505
A	HOH2500
A	HOH2546
A	HOH2561
A	HOH2580
A	HOH2685
A	TRP305
A	ARG1159
A	ARG1164
A	HOH1460

site_id	BC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 1312

Chain	Residue
A	HIS1086
A	ARG1126
A	PRO1127
A	GLN1128
A	THR1129
A	HOH1709
A	HOH2460
A	HOH2537
A	HOH2565
A	HOH2951

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 1313

Chain	Residue
A	GLN1176
A	GLY1184
A	MET1185
A	VAL1186
A	HOH1703
A	HOH1839
A	HOH2554
A	HOH2610
A	HOH2706

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1314

Chain	Residue
A	ALA911
A	HIS953
A	HOH1608
A	HOH1646
A	HOH1672

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1315

Chain	Residue
A	GLN767
A	ASP859
A	VAL860
A	ALA861
A	HOH1969

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1316

Chain	Residue
A	GLN54
A	PHE1112
A	HIS1114
A	HOH1859
A	HOH1864
A	HOH2215
A	HOH2699

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1317

Chain	Residue
A	LYS196
A	ASN1113
A	ARG1115
A	HOH1769

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1318

Chain	Residue
A	ASN1251
A	ARG1253
A	HOH2255
A	HOH2418
A	HOH2552

site_id	CC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1319

Chain	Residue
A	SER12
A	ALA13
A	PHE14
A	ASN998
A	HIS1161
A	HOH1759
A	HOH2430

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1320

Chain	Residue
A	THR632
A	ILE633
A	HOH1648
A	HOH1716
A	HOH2301
A	HOH2398

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1321

Chain	Residue
A	HIS68
A	THR69
A	HOH2680

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1322

Chain	Residue
A	SER-1
A	ARG-3
A	GLY-2
A	HIS152
A	HOH2548
A	HOH2599

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1323

Chain	Residue
A	GLY913
A	ASP914
A	ASP915
A	HOH1700
A	HOH2109

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 1324

Chain	Residue
A	VAL432
A	THR581
A	GLU582
A	GLU583
A	HOH2606
A	HOH2677

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 1325

Chain	Residue
A	ARG108
A	HOH1669
A	HOH2175
A	HOH2709
A	HOH2743
A	HOH2815

site_id	CC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT A 1326

Chain	Residue
A	THR247
A	LYS638
A	TRP984
A	HOH1804
A	HOH2160
A	HOH2324
A	HOH2636
A	HOH2710

site_id	CC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 1327

Chain	Residue
A	SER689
A	TYR691
A	VAL1229
A	THR1230
A	GLU1231
A	MG1338
A	HOH1825
A	HOH2055
A	HOH2259

site_id	DC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 1328

Chain	Residue
A	HIS902
A	CYS903
A	GLY961
A	ARG978
A	ASP1012
A	HOH1618
A	HOH1722
A	HOH2832

site_id	DC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GOL A 1329

Chain	Residue
A	GLU264
A	ALA267
A	PRO286
A	ASP1003
A	GLN1004
A	GLU1007
A	HOH1846
A	HOH2019
A	HOH2045
A	HOH2382
A	HOH2538
A	HOH2808

site_id	DC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 1330

Chain	Residue
A	ILE84
A	SER85
A	PRO86
A	MET136
A	ARG472
A	HOH1660
A	HOH1786
A	HOH1871
A	HOH2088

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1331

Chain	Residue
A	GLN52
A	ALA53
A	HOH2263
A	HOH2963

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1332

Chain	Residue
A	GLU1173
A	VAL1174
A	HOH2778

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1333

Chain	Residue
A	TRP1272
A	HIS1273
A	HOH1638

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1334

Chain	Residue
A	ALA1102
A	ASN1143
A	PHE1157
A	HOH1594

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1335

Chain	Residue
A	PHE1124
A	ASN1251
A	ARG1253
A	HOH1756

site_id	DC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1336

Chain	Residue
A	ALA384
A	LEU652
A	HOH1455
A	HOH1530

site_id	EC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 1337

Chain	Residue
A	PHE1169
A	HOH1470
A	HOH2998
A	HOH3007

site_id	EC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1338

Chain	Residue
A	ALA267
A	GLU1231
A	THR1232
A	GOL1327
A	HOH2055

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 1339

Chain	Residue
A	PHE1112
A	ASN1113
A	HOH1632
A	HOH2204

site_id	EC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1340

Chain	Residue
A	GLN727
A	HIS813
A	ALA875
A	PHE1226
A	HOH1990

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000255\|HAMAP-Rule:MF_00419

Chain	Residue	Details
A	CYG1135

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00419

Chain	Residue	Details
A	GLU1262
A	HIS1260

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00419

Chain	Residue	Details
A	GLY307

site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	SER886
A	THR386
A	ALA678

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00419, ECO:0000269\|PubMed:15301531, ECO:0000269\|PubMed:22683785, ECO:0000269\|PubMed:24223728

Chain	Residue	Details
A	GLU718
A	ASN722
A	ASP884
A	ASP679

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)