4LG0

Structure of a ternary FOXO1-ETS1 DNA complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Forkhead box protein O1	polymer	133	14788.6	1	UniProt (Q12778) Pfam (PF00250)	Homo sapiens (human)	Forkhead box protein O1A, Forkhead in rhabdomyosarcoma
2	B (B)	Protein C-ets-1	polymer	112	13174.1	1	UniProt (P14921) Pfam (PF00178)	Homo sapiens (human)	p54
3	C (C)	DNA (5'-D(*DTP*DTP*DCP*DAP*DCP*DGP*DGP*DTP*DTP*DTP*DCP*DCP*DTP*DGP*DTP*DTP*DAP*DTP*DTP*DGP*DT)-3')	polymer	21	6401.1	1
4	D (D)	DNA (5'-D(*DAP*DAP*DAP*DCP*DAP*DAP*DTP*DAP*DAP*DCP*DAP*DGP*DGP*DAP*DAP*DAP*DCP*DCP*DGP*DTP*DG)-3')	polymer	21	6482.3	1
5	E (A)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
6	F (B)	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
7	G, H, I, J (A, B, C, D)	water	water		18.0	70	Chemie (HOH)

Sequence modifications

A: 143 - 270 (UniProt: Q12778)

PDB	External Database	Details
Gly 138	-	expression tag
Pro 139	-	expression tag
Gly 140	-	expression tag
Tyr 141	-	expression tag
Pro 142	-	expression tag

B: 331 - 440 (UniProt: P14921)

PDB	External Database	Details
Met 329	-	expression tag
Gly 330	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	40846.1
Non-Polymers*	Number of molecules	2
	Total formula weight	234.3
All*	Total formula weight	41080.4

*Water molecules are not included.