4LG0

Structure of a ternary FOXO1-ETS1 DNA complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0043565	molecular_function	sequence-specific DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 301

Chain	Residue
A	LEU217
A	SER218
A	HIS220
A	PHE223
A	HOH408
C	HOH105

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 B 501

Chain	Residue
B	ASP417
B	TRP338
B	VAL415
B	CYS416

---

Functional Information from PROSITE/UniProt

site_id	PS00345
Number of Residues	9
Details	ETS_DOMAIN_1 Ets-domain signature 1. LWQFLLELL

Chain	Residue	Details
B	LEU337-LEU345

---

site_id	PS00346
Number of Residues	16
Details	ETS_DOMAIN_2 Ets-domain signature 2. KpkMnYEkLSRGLRyY

Chain	Residue	Details
B	LYS381-TYR396

---

site_id	PS00658
Number of Residues	7
Details	FORK_HEAD_2 Fork head domain signature 2. WKNSIRH

Chain	Residue	Details
A	TRP209-HIS215

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	DNA_BIND: ETS => ECO:0000255|PROSITE-ProRule:PRU00237

Chain	Residue	Details
B	ILE335-VAL415

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: DNA-binding => ECO:0000269|PubMed:18786403

Chain	Residue	Details
A	ASN158
A	TYR165
A	ARG225

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:21245099

Chain	Residue	Details
A	SER212

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403

Chain	Residue	Details
A	SER218
A	SER234
A	SER235

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9R1E0

Chain	Residue	Details
A	LYS245
A	LYS248

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:18356527

Chain	Residue	Details
A	SER249

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Omega-N-methylarginine; by PRMT1 => ECO:0000250|UniProtKB:Q9R1E0

Chain	Residue	Details
A	ARG251
A	ARG253

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKB/AKT1 and SGK1 => ECO:0000269|PubMed:10358075, ECO:0000269|PubMed:10358076, ECO:0000269|PubMed:11237865, ECO:0000269|PubMed:11980723, ECO:0000269|PubMed:31063815

Chain	Residue	Details
A	SER256

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:20543840

Chain	Residue	Details
A	LYS262
A	LYS265

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