4LG0
Structure of a ternary FOXO1-ETS1 DNA complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 301 |
| Chain | Residue |
| A | LEU217 |
| A | SER218 |
| A | HIS220 |
| A | PHE223 |
| A | HOH408 |
| C | HOH105 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PG4 B 501 |
| Chain | Residue |
| B | ASP417 |
| B | TRP338 |
| B | VAL415 |
| B | CYS416 |
Functional Information from PROSITE/UniProt
| site_id | PS00345 |
| Number of Residues | 9 |
| Details | ETS_DOMAIN_1 Ets-domain signature 1. LWQFLLELL |
| Chain | Residue | Details |
| B | LEU337-LEU345 |
| site_id | PS00346 |
| Number of Residues | 16 |
| Details | ETS_DOMAIN_2 Ets-domain signature 2. KpkMnYEkLSRGLRyY |
| Chain | Residue | Details |
| B | LYS381-TYR396 |
| site_id | PS00658 |
| Number of Residues | 7 |
| Details | FORK_HEAD_2 Fork head domain signature 2. WKNSIRH |
| Chain | Residue | Details |
| A | TRP209-HIS215 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 76 |
| Details | DNA binding: {"description":"Fork-head","evidences":[{"source":"PROSITE-ProRule","id":"PRU00089","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"18786403","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Site: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"18786403","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by STK4/MST1","evidences":[{"source":"PubMed","id":"18786403","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19221179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21245099","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine; by STK4/MST1","evidences":[{"source":"PubMed","id":"18786403","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 80 |
| Details | DNA binding: {"description":"ETS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00237","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Region: {"description":"Helix H4","evidences":[{"source":"UniProtKB","id":"P27577","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Region: {"description":"Helix H5","evidences":[{"source":"UniProtKB","id":"P27577","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
