4IOX

The structure of the herpes simplex virus DNA-packaging motor pUL15 C-terminal nuclease domain provides insights into cleavage of concatemeric viral genome precursors

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Tripartite terminase subunit UL15	polymer	286	30918.9	3	UniProt (P04295) Pfam (PF02499)	Human herpesvirus 1 (HHV-1)	DNA-packaging protein UL15, Terminase large subunit
2	D (D)	peptide	polymer	6	528.6	1		Human herpesvirus 1 (HHV-1)
3	E (A)	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
4	F (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
5	G (A)	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
6	H (A)	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
7	I, J, K (A, B, C)	water	water		18.0	46	Chemie (HOH)

Sequence modifications

A, B, C: 471 - 735 (UniProt: P04295)

PDB	External Database	Details
Met 450	-	expression tag
Gly 451	-	expression tag
Ser 452	-	expression tag
Ser 453	-	expression tag
His 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
His 457	-	expression tag
His 458	-	expression tag
His 459	-	expression tag
Ser 460	-	expression tag
Ser 461	-	expression tag
Gly 462	-	expression tag
Leu 463	-	expression tag
Val 464	-	expression tag
Pro 465	-	expression tag
Arg 466	-	expression tag
Gly 467	-	expression tag
Ser 468	-	expression tag
His 469	-	expression tag
Met 470	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	93285.4
Non-Polymers*	Number of molecules	4
	Total formula weight	509.6
All*	Total formula weight	93794.9

*Water molecules are not included.