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4IOX

The structure of the herpes simplex virus DNA-packaging motor pUL15 C-terminal nuclease domain provides insights into cleavage of concatemeric viral genome precursors

Functional Information from GO Data
ChainGOidnamespacecontents
A0051276biological_processchromosome organization
B0051276biological_processchromosome organization
C0051276biological_processchromosome organization
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE PGE A 801
ChainResidue
APRO491
ALEU499
ATYR529
AARG530
AHOH914
CLEU499
CTYR529
CARG530

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE PEG A 802
ChainResidue
AGLU599
AHIS595

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE PG4 A 803
ChainResidue
AARG577
AHIS597
ALEU618
APHE619
ATYR620
AHIS621
CGLU623

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ACT A 804
ChainResidue
AGLY626
CTHR598
CHIS601

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9
DetailsActive site: {"description":"For nuclease activity","evidences":[{"source":"HAMAP-Rule","id":"MF_04013","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23596306","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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