4HJJ
Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Interleukin-18 | polymer | 157 | 18067.5 | 1 | UniProt (Q14116) Pfam (PF00340) | Homo sapiens (human) | IL-18, Iboctadekin, Interferon gamma-inducing factor, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma |
| 2 | B (H) | Anti-IL12 Anti-IL18 DFab Heavy Chain | polymer | 348 | 37747.5 | 1 | Homo sapiens | ||
| 3 | C (L) | Anti-IL12 Anti-IL18 DFab Light Chain | polymer | 327 | 35774.5 | 1 | Homo sapiens | ||
| 4 | D, F (A, L) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | E (H) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | G (L) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 7 | H, I, J (A, H, L) | water | water | 18.0 | 846 | Chemie (HOH) |
Sequence modifications
A: 37 - 192 (UniProt: Q14116)
| PDB | External Database | Details |
|---|---|---|
| Ala 74 | Cys 74 | engineered mutation |
| Ala 104 | Cys 104 | engineered mutation |
| Ala 112 | Cys 112 | engineered mutation |
| Ala 163 | Cys 163 | engineered mutation |
| Ala 193 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 91589.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 315.7 | |
| All* | Total formula weight | 91905.2 |
