4HJJ

Structure Reveals Function of the Dual Variable Domain Immunoglobulin (DVD-Ig) Molecule

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005125	molecular_function	cytokine activity
A	0005615	cellular_component	extracellular space
A	0006954	biological_process	inflammatory response
A	0006955	biological_process	immune response

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 201

Chain	Residue
A	PRO143
A	GLY144
A	HOH345
A	HOH357
A	HOH369
H	ARG100

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 H 401

Chain	Residue
H	SER30
H	LYS73
H	LYS77
H	PHE24
H	SER28
H	LEU29

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site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL L 401

Chain	Residue
H	PHE300
H	PRO301
H	SER311
H	LEU312
H	SER313
L	GLN274
L	SER276
L	SER290
L	SER291
L	THR292
L	HOH796

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site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL L 402

Chain	Residue
L	LYS45

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
L	TYR306-HIS312
H	TYR328-HIS334

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage; by CASP3 => ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:9334240

Chain	Residue	Details
A	ASP71

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