4D8D
Crystal structure of HIV-1 NEF Fyn-SH3 R96W variant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Tyrosine-protein kinase Fyn | polymer | 58 | 6652.2 | 2 | UniProt (P06241) Pfam (PF00018) | Homo sapiens (human) | Proto-oncogene Syn, Proto-oncogene c-Fyn, Src-like kinase, SLK, p59-Fyn |
| 2 | B, D (B, D) | Protein Nef | polymer | 151 | 17568.7 | 2 | UniProt (P03406) Pfam (PF00469) | Human immunodeficiency virus type 1 (HIV-1) | 3'ORF, Negative factor, F-protein, C-terminal core protein |
| 3 | E (C) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | F, G, H, I (A, B, C, D) | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
A, C: 84 - 141 (UniProt: P06241)
B, D: 58 - 204 (UniProt: P03406)
| PDB | External Database | Details |
|---|---|---|
| Trp 96 | Arg 96 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 56 | - | expression tag |
| Ser 57 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 48441.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 92.1 | |
| All* | Total formula weight | 48534.0 |
