4CAK

Three-dimensional reconstruction of intact human integrin alphaIIbbeta3 in a phospholipid bilayer nanodisc

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Integrin alpha-IIb	polymer	959	104460.7	1	UniProt (P08514) Pfam (PF01839) Pfam (PF08441) Pfam (PF20805) Pfam (PF20806) In PDB	Homo sapiens (Human)	GPalpha IIb,GPIIb,Platelet membrane glycoprotein IIb
2	B	Integrin beta-3	polymer	690	76316.9	1	UniProt (P05106) Pfam (PF07965) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372) Pfam (PF07974) In PDB	Homo sapiens (Human)	Platelet membrane glycoprotein IIIa,GPIIIa
3	C, F	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	D	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
5	E	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
6	G	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G42227JK)
7	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

A: 1 - 959 (UniProt: P08514)

PDB	External Database	Details
Cys 959	Leu 990	conflict

B: 1 - 690 (UniProt: P05106)

PDB	External Database	Details
Cys 688	Pro 714	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	180777.7
Branched	Number of molecules	5
	Total formula weight	3094.8
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	184314.9

*Water molecules are not included.