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4CAK

Three-dimensional reconstruction of intact human integrin alphaIIbbeta3 in a phospholipid bilayer nanodisc

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0002687biological_processpositive regulation of leukocyte migration
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0007229biological_processintegrin-mediated signaling pathway
A0008305cellular_componentintegrin complex
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0016020cellular_componentmembrane
A0031092cellular_componentplatelet alpha granule membrane
A0033627biological_processcell adhesion mediated by integrin
A0042802molecular_functionidentical protein binding
A0046872molecular_functionmetal ion binding
A0050840molecular_functionextracellular matrix binding
A0060090molecular_functionmolecular adaptor activity
A0070051molecular_functionfibrinogen binding
A0070062cellular_componentextracellular exosome
A0070442cellular_componentintegrin alphaIIb-beta3 complex
A0072562cellular_componentblood microparticle
A0098609biological_processcell-cell adhesion
B0001618molecular_functionvirus receptor activity
B0001934biological_processpositive regulation of protein phosphorylation
B0001938biological_processpositive regulation of endothelial cell proliferation
B0001954biological_processpositive regulation of cell-matrix adhesion
B0001968molecular_functionfibronectin binding
B0002020molecular_functionprotease binding
B0002687biological_processpositive regulation of leukocyte migration
B0003756molecular_functionprotein disulfide isomerase activity
B0005080molecular_functionprotein kinase C binding
B0005161molecular_functionplatelet-derived growth factor receptor binding
B0005178molecular_functionintegrin binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0005925cellular_componentfocal adhesion
B0007044biological_processcell-substrate junction assembly
B0007155biological_processcell adhesion
B0007160biological_processcell-matrix adhesion
B0007229biological_processintegrin-mediated signaling pathway
B0007566biological_processembryo implantation
B0007596biological_processblood coagulation
B0008277biological_processregulation of G protein-coupled receptor signaling pathway
B0008305cellular_componentintegrin complex
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010595biological_processpositive regulation of endothelial cell migration
B0010628biological_processpositive regulation of gene expression
B0010745biological_processnegative regulation of macrophage derived foam cell differentiation
B0010763biological_processpositive regulation of fibroblast migration
B0010888biological_processnegative regulation of lipid storage
B0014823biological_processresponse to activity
B0014909biological_processsmooth muscle cell migration
B0014911biological_processpositive regulation of smooth muscle cell migration
B0015026molecular_functioncoreceptor activity
B0016324cellular_componentapical plasma membrane
B0017134molecular_functionfibroblast growth factor binding
B0019899molecular_functionenzyme binding
B0019960molecular_functionC-X3-C chemokine binding
B0030168biological_processplatelet activation
B0030335biological_processpositive regulation of cell migration
B0030949biological_processpositive regulation of vascular endothelial growth factor receptor signaling pathway
B0031092cellular_componentplatelet alpha granule membrane
B0031258cellular_componentlamellipodium membrane
B0031527cellular_componentfilopodium membrane
B0031528cellular_componentmicrovillus membrane
B0031589biological_processcell-substrate adhesion
B0031994molecular_functioninsulin-like growth factor I binding
B0032147biological_processactivation of protein kinase activity
B0032369biological_processnegative regulation of lipid transport
B0032587cellular_componentruffle membrane
B0032880biological_processregulation of protein localization
B0032956biological_processregulation of actin cytoskeleton organization
B0032991cellular_componentprotein-containing complex
B0033627biological_processcell adhesion mediated by integrin
B0033630biological_processpositive regulation of cell adhesion mediated by integrin
B0033690biological_processpositive regulation of osteoblast proliferation
B0034113biological_processheterotypic cell-cell adhesion
B0034446biological_processsubstrate adhesion-dependent cell spreading
B0034683cellular_componentintegrin alphav-beta3 complex
B0035295biological_processtube development
B0035313biological_processwound healing, spreading of epidermal cells
B0035866cellular_componentalphav-beta3 integrin-PKCalpha complex
B0035867cellular_componentalphav-beta3 integrin-IGF-1-IGF1R complex
B0035868cellular_componentalphav-beta3 integrin-HMGB1 complex
B0036119biological_processresponse to platelet-derived growth factor
B0036120biological_processcellular response to platelet-derived growth factor stimulus
B0038027biological_processapolipoprotein A-I-mediated signaling pathway
B0038132molecular_functionneuregulin binding
B0042060biological_processwound healing
B0042470cellular_componentmelanosome
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043184molecular_functionvascular endothelial growth factor receptor 2 binding
B0043235cellular_componentreceptor complex
B0043277biological_processapoptotic cell clearance
B0045124biological_processregulation of bone resorption
B0045202cellular_componentsynapse
B0045211cellular_componentpostsynaptic membrane
B0045766biological_processpositive regulation of angiogenesis
B0045780biological_processpositive regulation of bone resorption
B0046718biological_processsymbiont entry into host cell
B0046872molecular_functionmetal ion binding
B0048008biological_processplatelet-derived growth factor receptor signaling pathway
B0048146biological_processpositive regulation of fibroblast proliferation
B0048333biological_processmesodermal cell differentiation
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
B0050748biological_processnegative regulation of lipoprotein metabolic process
B0050839molecular_functioncell adhesion molecule binding
B0050840molecular_functionextracellular matrix binding
B0050919biological_processnegative chemotaxis
B0051279biological_processregulation of release of sequestered calcium ion into cytosol
B0051611biological_processregulation of serotonin uptake
B0060055biological_processangiogenesis involved in wound healing
B0070051molecular_functionfibrinogen binding
B0070062cellular_componentextracellular exosome
B0070161cellular_componentanchoring junction
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0070442cellular_componentintegrin alphaIIb-beta3 complex
B0070527biological_processplatelet aggregation
B0071062cellular_componentalphav-beta3 integrin-vitronectin complex
B0071133cellular_componentalpha9-beta1 integrin-ADAM8 complex
B0071260biological_processcellular response to mechanical stimulus
B0071466biological_processcellular response to xenobiotic stimulus
B0072126biological_processpositive regulation of glomerular mesangial cell proliferation
B0072378biological_processblood coagulation, fibrin clot formation
B0097060cellular_componentsynaptic membrane
B0098690cellular_componentglycinergic synapse
B0098880biological_processmaintenance of postsynaptic specialization structure
B0098978cellular_componentglutamatergic synapse
B0099149biological_processregulation of postsynaptic neurotransmitter receptor internalization
B0150054biological_processregulation of postsynaptic neurotransmitter receptor diffusion trapping
B1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
B1900731biological_processpositive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway
B1901163biological_processregulation of trophoblast cell migration
B1903053biological_processregulation of extracellular matrix organization
B1905598biological_processnegative regulation of low-density lipoprotein receptor activity
B1990314biological_processcellular response to insulin-like growth factor stimulus
B2000352biological_processnegative regulation of endothelial cell apoptotic process
B2000406biological_processpositive regulation of T cell migration
Functional Information from PROSITE/UniProt
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CrCgpGwlGSqC
ChainResidueDetails
BCYS460-CYS471
BCYS547-CYS558

site_idPS00243
Number of Residues14
DetailsINTEGRIN_BETA Integrins beta chain cysteine-rich domain signature. CsQr..GeClCgqCvC
ChainResidueDetails
BCYS495-CYS508
BCYS536-CYS549
BCYS575-CYS588

site_idPS01186
Number of Residues14
DetailsEGF_2 EGF-like domain signature 2. CrCgpGWlgsqce..C
ChainResidueDetails
BCYS460-CYS473

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
ChainResidueDetails
BSER121
AASP305
AASP365
AASP367
AASP369
ATYR371
AASP373
AASP426
AASP428
AASN430
ATYR432
BGLU220
AASP434
AASP247
ATHR250
AGLU252
AASP297
AASN299
AASP301
AARG303

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: in MIDAS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCU
ChainResidueDetails
BSER123

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: in ADMIDAS binding site => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU, ECO:0007744|PDB:3IJE
ChainResidueDetails
BASP126
BASP127

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: in LIMBS binding site => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3FCU
ChainResidueDetails
BASP158
BASN215
BASP217
BPRO219

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: in LIMBS binding site => ECO:0007744|PDB:4G1M
ChainResidueDetails
BASP251

site_idSWS_FT_FI6
Number of Residues1
DetailsBINDING: in ADMIDAS binding site and unliganded-closed conformation => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:3FCS, ECO:0007744|PDB:3IJE
ChainResidueDetails
BMET335

site_idSWS_FT_FI7
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE
ChainResidueDetails
BASN99

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:15378069, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:1TYE, ECO:0007744|PDB:3IJE
ChainResidueDetails
BASN320
BASN371

site_idSWS_FT_FI9
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:3IJE
ChainResidueDetails
BASN452

site_idSWS_FT_FI10
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19111664, ECO:0000269|PubMed:19704023, ECO:0007744|PDB:1JV2, ECO:0007744|PDB:3IJE
ChainResidueDetails
BASN559

site_idSWS_FT_FI11
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11546839, ECO:0000269|PubMed:19159218, ECO:0007744|PDB:1JV2
ChainResidueDetails
BASN654

221371

PDB entries from 2024-06-19

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