4A04

Structure of the DNA-bound T-box domain of human TBX1, a transcription factor associated with the DiGeorge syndrome

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	T-BOX TRANSCRIPTION FACTOR TBX1	polymer	203	23834.2	2	UniProt (O43435) Pfam (PF00907)	HOMO SAPIENS (HUMAN)	TBX1, T-BOX PROTEIN 1, TESTIS-SPECIFIC T-BOX PROTEIN
2	C, D (D, E)	DNA	polymer	24	7367.8	2		HOMO SAPIENS
3	E, F, G, H (A, B, D, E)	water	water		18.0	66	Chemie (HOH)

Sequence modifications

A, B: 109 - 297 (UniProt: O43435)

PDB	External Database	Details
Met 95	-	expression tag
His 96	-	expression tag
His 97	-	expression tag
His 98	-	expression tag
His 99	-	expression tag
His 100	-	expression tag
His 101	-	expression tag
Glu 102	-	expression tag
Asn 103	-	expression tag
Leu 104	-	expression tag
Tyr 105	-	expression tag
Phe 106	-	expression tag
Gln 107	-	expression tag
Gly 108	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	62403.9
All*	Total formula weight	62403.9

*Water molecules are not included.