4A04

Structure of the DNA-bound T-box domain of human TBX1, a transcription factor associated with the DiGeorge syndrome

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription
B	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005634	cellular_component	nucleus
B	0006355	biological_process	regulation of DNA-templated transcription
B	0045893	biological_process	positive regulation of DNA-templated transcription

Functional Information from PROSITE/UniProt

site_id	PS01264
Number of Residues	19
Details	TBOX_2 T-box domain signature 2. YHPDSpakGaqWMkqiVsF

Chain	Residue	Details
A	TYR195-PHE213

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site_id	PS01283
Number of Residues	20
Details	TBOX_1 T-box domain signature 1. LWdeFnqlgTEMIVTkaGRR

Chain	Residue	Details
A	LEU119-ARG138

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	356
Details	DNA_BIND: T-box => ECO:0000255|PROSITE-ProRule:PRU00201

Chain	Residue	Details
A	LEU119-ASP297
B	LEU119-ASP297

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