3ZY7
Crystal structure of computationally redesigned gamma-adaptin appendage domain forming a symmetric homodimer
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | AP-1 COMPLEX SUBUNIT GAMMA-1 | polymer | 122 | 13637.4 | 2 | UniProt (P22892) Pfam (PF02883) In PDB | MUS MUSCULUS (HOUSE MOUSE) | REDESIGNED CLATHRIN ADAPTOR AP1, ADAPTER-RELATED PROTEIN CO ADAPTOR PROTEIN COMPLEX AP-1 SUBUNIT GAMMA-1, CLATHRIN ASSEMBLY PROTEIN COMPLEX 1 GAMMA-1 LARGE CHAIN, GAMMA-ADAPTIN, GAMMA1-ADAPTIN, GOLGI ADAPTOR HA1/AP1 ADAPTIN SUBUNIT GAMMA-1 |
2 | A, B | ISOPROPYL ALCOHOL | non-polymer | 60.1 | 2 | Chemie (IPA) | |||
3 | B | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
4 | water | water | 18.0 | 298 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 120 (UniProt: P22892)
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Met 1 | - | expression tag |
Asp 9 | Ser 711 | engineered mutation |
Ala 10 | Lys 712 | engineered mutation |
Leu 11 | Asn 713 | engineered mutation |
Phe 98 | Tyr 800 | engineered mutation |
Trp 100 | His 802 | engineered mutation |
Asn 101 | Lys 803 | engineered mutation |
Tyr 103 | Ser 805 | engineered mutation |
Lys 104 | Ala 806 | engineered mutation |
Val 105 | Met 807 | engineered mutation |
Ser 107 | Asp 809 | engineered mutation |
Glu 108 | Leu 810 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 27274.9 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 332.4 | |
All* | Total formula weight | 27607.3 |