3SDJ
Structure of RNase-inactive point mutant of oligomeric kinase/RNase Ire1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | Serine/threonine-protein kinase/endoribonuclease IRE1 | polymer | 448 | 51859.3 | 14 | UniProt (P32361) Pfam (PF00069) Pfam (PF06479) In PDB | Saccharomyces cerevisiae (Baker's yeast) | Endoplasmic reticulum-to-nucleus signaling 1, Serine/threonine-protein kinase, Endoribonuclease |
| 2 | M, N, A, B, C... | N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine | non-polymer | 332.4 | 14 | Chemie (APJ) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L, M, N: 641 - 1115 (UniProt: P32361)
| PDB | External Database | Details |
|---|---|---|
| Pro 640 | - | EXPRESSION TAG |
| - | Asn 865 | DELETION |
| - | Asn 866 | DELETION |
| - | Leu 867 | DELETION |
| - | Gln 868 | DELETION |
| - | Cys 869 | DELETION |
| - | Gln 870 | DELETION |
| - | Val 871 | DELETION |
| - | Glu 872 | DELETION |
| - | Thr 873 | DELETION |
| - | Glu 874 | DELETION |
| - | His 875 | DELETION |
| - | Ser 876 | DELETION |
| - | Ser 877 | DELETION |
| - | Ser 878 | DELETION |
| - | Arg 879 | DELETION |
| - | His 880 | DELETION |
| - | Thr 881 | DELETION |
| - | Val 882 | DELETION |
| - | Val 883 | DELETION |
| - | Ser 884 | DELETION |
| - | Ser 885 | DELETION |
| - | Asp 886 | DELETION |
| - | Ser 887 | DELETION |
| - | Phe 888 | DELETION |
| - | Tyr 889 | DELETION |
| - | Asp 890 | DELETION |
| - | Pro 891 | DELETION |
| - | Phe 892 | DELETION |
| Asn 1061 | His 1061 | ENGINEERED MUTATION |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 726030.9 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 4653.1 | |
| All* | Total formula weight | 730684.0 |
