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3SDJ

Structure of RNase-inactive point mutant of oligomeric kinase/RNase Ire1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004521molecular_functionRNA endonuclease activity
A0004540molecular_functionRNA nuclease activity
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005524molecular_functionATP binding
A0006397biological_processmRNA processing
A0006468biological_processprotein phosphorylation
A0030968biological_processendoplasmic reticulum unfolded protein response
B0004521molecular_functionRNA endonuclease activity
B0004540molecular_functionRNA nuclease activity
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0005524molecular_functionATP binding
B0006397biological_processmRNA processing
B0006468biological_processprotein phosphorylation
B0030968biological_processendoplasmic reticulum unfolded protein response
C0004521molecular_functionRNA endonuclease activity
C0004540molecular_functionRNA nuclease activity
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0005524molecular_functionATP binding
C0006397biological_processmRNA processing
C0006468biological_processprotein phosphorylation
C0030968biological_processendoplasmic reticulum unfolded protein response
D0004521molecular_functionRNA endonuclease activity
D0004540molecular_functionRNA nuclease activity
D0004672molecular_functionprotein kinase activity
D0004674molecular_functionprotein serine/threonine kinase activity
D0005524molecular_functionATP binding
D0006397biological_processmRNA processing
D0006468biological_processprotein phosphorylation
D0030968biological_processendoplasmic reticulum unfolded protein response
E0004521molecular_functionRNA endonuclease activity
E0004540molecular_functionRNA nuclease activity
E0004672molecular_functionprotein kinase activity
E0004674molecular_functionprotein serine/threonine kinase activity
E0005524molecular_functionATP binding
E0006397biological_processmRNA processing
E0006468biological_processprotein phosphorylation
E0030968biological_processendoplasmic reticulum unfolded protein response
F0004521molecular_functionRNA endonuclease activity
F0004540molecular_functionRNA nuclease activity
F0004672molecular_functionprotein kinase activity
F0004674molecular_functionprotein serine/threonine kinase activity
F0005524molecular_functionATP binding
F0006397biological_processmRNA processing
F0006468biological_processprotein phosphorylation
F0030968biological_processendoplasmic reticulum unfolded protein response
G0004521molecular_functionRNA endonuclease activity
G0004540molecular_functionRNA nuclease activity
G0004672molecular_functionprotein kinase activity
G0004674molecular_functionprotein serine/threonine kinase activity
G0005524molecular_functionATP binding
G0006397biological_processmRNA processing
G0006468biological_processprotein phosphorylation
G0030968biological_processendoplasmic reticulum unfolded protein response
H0004521molecular_functionRNA endonuclease activity
H0004540molecular_functionRNA nuclease activity
H0004672molecular_functionprotein kinase activity
H0004674molecular_functionprotein serine/threonine kinase activity
H0005524molecular_functionATP binding
H0006397biological_processmRNA processing
H0006468biological_processprotein phosphorylation
H0030968biological_processendoplasmic reticulum unfolded protein response
I0004521molecular_functionRNA endonuclease activity
I0004540molecular_functionRNA nuclease activity
I0004672molecular_functionprotein kinase activity
I0004674molecular_functionprotein serine/threonine kinase activity
I0005524molecular_functionATP binding
I0006397biological_processmRNA processing
I0006468biological_processprotein phosphorylation
I0030968biological_processendoplasmic reticulum unfolded protein response
J0004521molecular_functionRNA endonuclease activity
J0004540molecular_functionRNA nuclease activity
J0004672molecular_functionprotein kinase activity
J0004674molecular_functionprotein serine/threonine kinase activity
J0005524molecular_functionATP binding
J0006397biological_processmRNA processing
J0006468biological_processprotein phosphorylation
J0030968biological_processendoplasmic reticulum unfolded protein response
K0004521molecular_functionRNA endonuclease activity
K0004540molecular_functionRNA nuclease activity
K0004672molecular_functionprotein kinase activity
K0004674molecular_functionprotein serine/threonine kinase activity
K0005524molecular_functionATP binding
K0006397biological_processmRNA processing
K0006468biological_processprotein phosphorylation
K0030968biological_processendoplasmic reticulum unfolded protein response
L0004521molecular_functionRNA endonuclease activity
L0004540molecular_functionRNA nuclease activity
L0004672molecular_functionprotein kinase activity
L0004674molecular_functionprotein serine/threonine kinase activity
L0005524molecular_functionATP binding
L0006397biological_processmRNA processing
L0006468biological_processprotein phosphorylation
L0030968biological_processendoplasmic reticulum unfolded protein response
M0004521molecular_functionRNA endonuclease activity
M0004540molecular_functionRNA nuclease activity
M0004672molecular_functionprotein kinase activity
M0004674molecular_functionprotein serine/threonine kinase activity
M0005524molecular_functionATP binding
M0006397biological_processmRNA processing
M0006468biological_processprotein phosphorylation
M0030968biological_processendoplasmic reticulum unfolded protein response
N0004521molecular_functionRNA endonuclease activity
N0004540molecular_functionRNA nuclease activity
N0004672molecular_functionprotein kinase activity
N0004674molecular_functionprotein serine/threonine kinase activity
N0005524molecular_functionATP binding
N0006397biological_processmRNA processing
N0006468biological_processprotein phosphorylation
N0030968biological_processendoplasmic reticulum unfolded protein response
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE APJ A 1999
ChainResidue
ALEU680
ATYR682
AALA700
ALEU745
AGLU746
ACYS748
AASN751
ALEU804

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE APJ B 1999
ChainResidue
BTYR682
BALA700
BLEU745
BGLU746
BCYS748
BASN751
BLEU804
BLEU680

site_idAC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE APJ C 1999
ChainResidue
CLEU680
CTYR682
CALA700
CLEU745
CGLU746
CCYS748
CASN751
CLEU804

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE APJ D 1999
ChainResidue
DLEU680
DTYR682
DALA700
DLEU745
DGLU746
DCYS748
DASN751
DLEU804

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE APJ E 1999
ChainResidue
ELEU680
ETYR682
EALA700
EGLU746
ECYS748
EASN751
ELEU804

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE APJ F 1999
ChainResidue
FLEU680
FTYR682
FALA700
FLEU745
FGLU746
FCYS748
FASN751
FLEU804

site_idAC7
Number of Residues8
DetailsBINDING SITE FOR RESIDUE APJ G 1999
ChainResidue
GLEU680
GTYR682
GALA700
GLEU745
GGLU746
GCYS748
GASN751
GLEU804

site_idAC8
Number of Residues8
DetailsBINDING SITE FOR RESIDUE APJ H 1999
ChainResidue
HLEU680
HTYR682
HALA700
HLEU745
HGLU746
HCYS748
HASN751
HLEU804

site_idAC9
Number of Residues7
DetailsBINDING SITE FOR RESIDUE APJ I 1999
ChainResidue
ILEU680
ITYR682
IALA700
IGLU746
ICYS748
IASN751
ILEU804

site_idBC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE APJ J 1999
ChainResidue
JLEU680
JTYR682
JALA700
JLEU745
JGLU746
JCYS748
JASN751
JLEU804

site_idBC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE APJ K 1999
ChainResidue
KLEU680
KTYR682
KALA700
KGLU746
KCYS748
KASN751
KLEU804

site_idBC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE APJ L 1999
ChainResidue
LLEU680
LTYR682
LALA700
LLEU745
LGLU746
LCYS748
LASN751
LLEU804

site_idBC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE APJ M 1999
ChainResidue
MASN751
MLEU804
MLEU680
MTYR682
MALA700
MLEU745
MGLU746
MCYS748

site_idBC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE APJ N 1999
ChainResidue
NLEU680
NTYR682
NALA700
NLEU745
NGLU746
NCYS748
NASN751
NLEU804

Functional Information from PROSITE/UniProt
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpqNILV
ChainResidueDetails
AILE793-VAL805

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP797
JASP797
KASP797
LASP797
MASP797
NASP797
BASP797
CASP797
DASP797
EASP797
FASP797
GASP797
HASP797
IASP797

site_idSWS_FT_FI2
Number of Residues14
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU680
JLEU680
KLEU680
LLEU680
MLEU680
NLEU680
BLEU680
CLEU680
DLEU680
ELEU680
FLEU680
GLEU680
HLEU680
ILEU680

site_idSWS_FT_FI3
Number of Residues14
DetailsBINDING:
ChainResidueDetails
ALYS702
JLYS702
KLYS702
LLYS702
MLYS702
NLYS702
BLYS702
CLYS702
DLYS702
ELYS702
FLYS702
GLYS702
HLYS702
ILYS702

site_idSWS_FT_FI4
Number of Residues28
DetailsMOD_RES: Phosphoserine; by autocatalysis => ECO:0000305|PubMed:8670804
ChainResidueDetails
ASEP840
ESEP841
FSEP840
FSEP841
GSEP840
GSEP841
HSEP840
HSEP841
ISEP840
ISEP841
JSEP840
ASEP841
JSEP841
KSEP840
KSEP841
LSEP840
LSEP841
MSEP840
MSEP841
NSEP840
NSEP841
BSEP840
BSEP841
CSEP840
CSEP841
DSEP840
DSEP841
ESEP840

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PDB entries from 2024-07-17

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