Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3SDJ

Structure of RNase-inactive point mutant of oligomeric kinase/RNase Ire1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004521	molecular_function	RNA endonuclease activity
A	0004540	molecular_function	RNA nuclease activity
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006397	biological_process	mRNA processing
A	0006468	biological_process	protein phosphorylation
A	0030968	biological_process	endoplasmic reticulum unfolded protein response
B	0004521	molecular_function	RNA endonuclease activity
B	0004540	molecular_function	RNA nuclease activity
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005524	molecular_function	ATP binding
B	0006397	biological_process	mRNA processing
B	0006468	biological_process	protein phosphorylation
B	0030968	biological_process	endoplasmic reticulum unfolded protein response
C	0004521	molecular_function	RNA endonuclease activity
C	0004540	molecular_function	RNA nuclease activity
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005524	molecular_function	ATP binding
C	0006397	biological_process	mRNA processing
C	0006468	biological_process	protein phosphorylation
C	0030968	biological_process	endoplasmic reticulum unfolded protein response
D	0004521	molecular_function	RNA endonuclease activity
D	0004540	molecular_function	RNA nuclease activity
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0005524	molecular_function	ATP binding
D	0006397	biological_process	mRNA processing
D	0006468	biological_process	protein phosphorylation
D	0030968	biological_process	endoplasmic reticulum unfolded protein response
E	0004521	molecular_function	RNA endonuclease activity
E	0004540	molecular_function	RNA nuclease activity
E	0004672	molecular_function	protein kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0005524	molecular_function	ATP binding
E	0006397	biological_process	mRNA processing
E	0006468	biological_process	protein phosphorylation
E	0030968	biological_process	endoplasmic reticulum unfolded protein response
F	0004521	molecular_function	RNA endonuclease activity
F	0004540	molecular_function	RNA nuclease activity
F	0004672	molecular_function	protein kinase activity
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0005524	molecular_function	ATP binding
F	0006397	biological_process	mRNA processing
F	0006468	biological_process	protein phosphorylation
F	0030968	biological_process	endoplasmic reticulum unfolded protein response
G	0004521	molecular_function	RNA endonuclease activity
G	0004540	molecular_function	RNA nuclease activity
G	0004672	molecular_function	protein kinase activity
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0005524	molecular_function	ATP binding
G	0006397	biological_process	mRNA processing
G	0006468	biological_process	protein phosphorylation
G	0030968	biological_process	endoplasmic reticulum unfolded protein response
H	0004521	molecular_function	RNA endonuclease activity
H	0004540	molecular_function	RNA nuclease activity
H	0004672	molecular_function	protein kinase activity
H	0004674	molecular_function	protein serine/threonine kinase activity
H	0005524	molecular_function	ATP binding
H	0006397	biological_process	mRNA processing
H	0006468	biological_process	protein phosphorylation
H	0030968	biological_process	endoplasmic reticulum unfolded protein response
I	0004521	molecular_function	RNA endonuclease activity
I	0004540	molecular_function	RNA nuclease activity
I	0004672	molecular_function	protein kinase activity
I	0004674	molecular_function	protein serine/threonine kinase activity
I	0005524	molecular_function	ATP binding
I	0006397	biological_process	mRNA processing
I	0006468	biological_process	protein phosphorylation
I	0030968	biological_process	endoplasmic reticulum unfolded protein response
J	0004521	molecular_function	RNA endonuclease activity
J	0004540	molecular_function	RNA nuclease activity
J	0004672	molecular_function	protein kinase activity
J	0004674	molecular_function	protein serine/threonine kinase activity
J	0005524	molecular_function	ATP binding
J	0006397	biological_process	mRNA processing
J	0006468	biological_process	protein phosphorylation
J	0030968	biological_process	endoplasmic reticulum unfolded protein response
K	0004521	molecular_function	RNA endonuclease activity
K	0004540	molecular_function	RNA nuclease activity
K	0004672	molecular_function	protein kinase activity
K	0004674	molecular_function	protein serine/threonine kinase activity
K	0005524	molecular_function	ATP binding
K	0006397	biological_process	mRNA processing
K	0006468	biological_process	protein phosphorylation
K	0030968	biological_process	endoplasmic reticulum unfolded protein response
L	0004521	molecular_function	RNA endonuclease activity
L	0004540	molecular_function	RNA nuclease activity
L	0004672	molecular_function	protein kinase activity
L	0004674	molecular_function	protein serine/threonine kinase activity
L	0005524	molecular_function	ATP binding
L	0006397	biological_process	mRNA processing
L	0006468	biological_process	protein phosphorylation
L	0030968	biological_process	endoplasmic reticulum unfolded protein response
M	0004521	molecular_function	RNA endonuclease activity
M	0004540	molecular_function	RNA nuclease activity
M	0004672	molecular_function	protein kinase activity
M	0004674	molecular_function	protein serine/threonine kinase activity
M	0005524	molecular_function	ATP binding
M	0006397	biological_process	mRNA processing
M	0006468	biological_process	protein phosphorylation
M	0030968	biological_process	endoplasmic reticulum unfolded protein response
N	0004521	molecular_function	RNA endonuclease activity
N	0004540	molecular_function	RNA nuclease activity
N	0004672	molecular_function	protein kinase activity
N	0004674	molecular_function	protein serine/threonine kinase activity
N	0005524	molecular_function	ATP binding
N	0006397	biological_process	mRNA processing
N	0006468	biological_process	protein phosphorylation
N	0030968	biological_process	endoplasmic reticulum unfolded protein response

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE APJ A 1999

Chain	Residue
A	LEU680
A	TYR682
A	ALA700
A	LEU745
A	GLU746
A	CYS748
A	ASN751
A	LEU804

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE APJ B 1999

Chain	Residue
B	TYR682
B	ALA700
B	LEU745
B	GLU746
B	CYS748
B	ASN751
B	LEU804
B	LEU680

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE APJ C 1999

Chain	Residue
C	LEU680
C	TYR682
C	ALA700
C	LEU745
C	GLU746
C	CYS748
C	ASN751
C	LEU804

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE APJ D 1999

Chain	Residue
D	LEU680
D	TYR682
D	ALA700
D	LEU745
D	GLU746
D	CYS748
D	ASN751
D	LEU804

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE APJ E 1999

Chain	Residue
E	LEU680
E	TYR682
E	ALA700
E	GLU746
E	CYS748
E	ASN751
E	LEU804

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE APJ F 1999

Chain	Residue
F	LEU680
F	TYR682
F	ALA700
F	LEU745
F	GLU746
F	CYS748
F	ASN751
F	LEU804

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE APJ G 1999

Chain	Residue
G	LEU680
G	TYR682
G	ALA700
G	LEU745
G	GLU746
G	CYS748
G	ASN751
G	LEU804

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE APJ H 1999

Chain	Residue
H	LEU680
H	TYR682
H	ALA700
H	LEU745
H	GLU746
H	CYS748
H	ASN751
H	LEU804

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE APJ I 1999

Chain	Residue
I	LEU680
I	TYR682
I	ALA700
I	GLU746
I	CYS748
I	ASN751
I	LEU804

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE APJ J 1999

Chain	Residue
J	LEU680
J	TYR682
J	ALA700
J	LEU745
J	GLU746
J	CYS748
J	ASN751
J	LEU804

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE APJ K 1999

Chain	Residue
K	LEU680
K	TYR682
K	ALA700
K	GLU746
K	CYS748
K	ASN751
K	LEU804

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE APJ L 1999

Chain	Residue
L	LEU680
L	TYR682
L	ALA700
L	LEU745
L	GLU746
L	CYS748
L	ASN751
L	LEU804

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE APJ M 1999

Chain	Residue
M	ASN751
M	LEU804
M	LEU680
M	TYR682
M	ALA700
M	LEU745
M	GLU746
M	CYS748

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE APJ N 1999

Chain	Residue
N	LEU680
N	TYR682
N	ALA700
N	LEU745
N	GLU746
N	CYS748
N	ASN751
N	LEU804

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKpqNILV

Chain	Residue	Details
A	ILE793-VAL805

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	98
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18191223","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2RIO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	28
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"18191223","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8670804","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	14
Details	Modified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"PubMed","id":"18191223","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)