3S8L

Protein-Ligand Interactions: Thermodynamic Effects Associated with Increasing Hydrophobic Surface Area

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Growth factor receptor-bound protein 2	polymer	117	13758.5	1	UniProt (P62993) Pfam (PF00017) In PDB	Homo sapiens (human)	Adapter protein GRB2, Protein Ash, SH2/SH3 adapter GRB2
2	B	pYAc4cN	polymer	5	496.4	1
3	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
4	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5		water	water		18.0	58	Chemie (HOH)

Sequence modifications

A: 53 - 163 (UniProt: P62993)

PDB	External Database	Details
His 164	-	expression tag
His 165	-	expression tag
His 166	-	expression tag
His 167	-	expression tag
His 168	-	expression tag
His 169	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	14255.0
Non-Polymers*	Number of molecules	2
	Total formula weight	127.5
All*	Total formula weight	14382.5

*Water molecules are not included.