3QL0
Crystal structure of N23PP/S148A mutant of E. coli dihydrofolate reductase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydrofolate reductase | polymer | 160 | 18083.5 | 1 | UniProt (Q1RGF0) | Escherichia coli | |
| 2 | B (A) | FOLIC ACID | non-polymer | 441.4 | 1 | Chemie (FOL) | |||
| 3 | C (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 4 | D, E, F (A) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 5 | G (A) | water | water | 18.0 | 199 | Chemie (HOH) |
Sequence modifications
A: 1 - 159 (UniProt: Q1RGF0)
| PDB | External Database | Details |
|---|---|---|
| Pro 23 | Asn 68 | engineered mutation |
| Pro 23 | - | insertion |
| Ala 148 | Ser 193 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18083.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1253.8 | |
| All* | Total formula weight | 19337.2 |
