Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE FOL A 160 |
| Chain | Residue |
| A | ILE5 |
| A | ARG57 |
| A | ILE94 |
| A | TYR100 |
| A | THR113 |
| A | NAP161 |
| A | HOH180 |
| A | HOH183 |
| A | HOH216 |
| A | HOH226 |
| A | HOH232 |
| A | ALA6 |
| A | HOH239 |
| A | HOH268 |
| A | HOH274 |
| A | HOH277 |
| A | ALA7 |
| A | MET20 |
| A | ASP27 |
| A | LEU28 |
| A | PHE31 |
| A | LYS32 |
| A | ILE50 |
| site_id | AC2 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE NAP A 161 |
| Chain | Residue |
| A | ALA6 |
| A | ALA7 |
| A | ILE14 |
| A | GLY15 |
| A | ASN18 |
| A | ALA19 |
| A | MET20 |
| A | GLY43 |
| A | ARG44 |
| A | HIS45 |
| A | THR46 |
| A | LEU62 |
| A | SER63 |
| A | SER64 |
| A | GLN65 |
| A | LYS76 |
| A | ILE94 |
| A | GLY96 |
| A | GLY97 |
| A | ARG98 |
| A | VAL99 |
| A | TYR100 |
| A | GLN102 |
| A | THR123 |
| A | FOL160 |
| A | HOH199 |
| A | HOH217 |
| A | HOH229 |
| A | HOH236 |
| A | HOH246 |
| A | HOH250 |
| A | HOH259 |
| A | HOH281 |
| A | HOH309 |
| A | HOH351 |
| A | HOH358 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA A 162 |
| Chain | Residue |
| A | ASP87 |
| A | ASP116 |
| A | SER150 |
| A | HOH177 |
| A | HOH223 |
| A | HOH255 |
| A | HOH286 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA A 163 |
| Chain | Residue |
| A | SER135 |
| A | HOH170 |
| A | HOH171 |
| A | HOH174 |
| A | HOH175 |
| A | HOH209 |
| A | HOH210 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA A 164 |
| Chain | Residue |
| A | ASP87 |
| A | ASP116 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 24 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWpplpaDlawFkrnT |
| Chain | Residue | Details |
| A | VAL13-THR35 | |
