3O0G
Crystal Structure of Cdk5:p25 in complex with an ATP analogue
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | Cell division protein kinase 5 | polymer | 292 | 33349.5 | 2 | UniProt (Q00535) Pfam (PF00069) | Homo sapiens (human) | Cyclin-dependent kinase 5, Tau protein kinase II catalytic subunit, TPKII catalytic subunit, Serine/threonine-protein kinase PSSALRE |
| 2 | B, D (D, E) | Cyclin-dependent kinase 5 activator 1 | polymer | 149 | 17216.9 | 2 | UniProt (Q15078) Pfam (PF03261) | Homo sapiens (human) | CDK5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1, TPKII regulatory subunit, Cyclin-dependent kinase 5 activator 1, p25, p25, Tau protein kinase II 23 kDa subunit, p23 |
| 3 | E (B) | {4-amino-2-[(4-chlorophenyl)amino]-1,3-thiazol-5-yl}(3-nitrophenyl)methanone | non-polymer | 374.8 | 1 | Chemie (3O0) | |||
| 4 | F, G, H, I (A, D, B, E) | water | water | 18.0 | 234 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 292 (UniProt: Q00535)
| PDB | External Database | Details |
|---|---|---|
| Asn 144 | Asp 144 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 101132.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 374.8 | |
| All* | Total formula weight | 101507.5 |
