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3O0G

Crystal Structure of Cdk5:p25 in complex with an ATP analogue

Functional Information from GO Data
ChainGOidnamespacecontents
A0000226biological_processmicrotubule cytoskeleton organization
A0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
A0001764biological_processneuron migration
A0001963biological_processsynaptic transmission, dopaminergic
A0002039molecular_functionp53 binding
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
A0005176molecular_functionErbB-2 class receptor binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005874cellular_componentmicrotubule
A0005886cellular_componentplasma membrane
A0006468biological_processprotein phosphorylation
A0006886biological_processintracellular protein transport
A0006915biological_processapoptotic process
A0007160biological_processcell-matrix adhesion
A0007268biological_processchemical synaptic transmission
A0007399biological_processnervous system development
A0007409biological_processaxonogenesis
A0007416biological_processsynapse assembly
A0007519biological_processskeletal muscle tissue development
A0008017molecular_functionmicrotubule binding
A0008045biological_processmotor neuron axon guidance
A0008306biological_processassociative learning
A0008542biological_processvisual learning
A0014044biological_processSchwann cell development
A0014069cellular_componentpostsynaptic density
A0016020cellular_componentmembrane
A0016079biological_processsynaptic vesicle exocytosis
A0016241biological_processregulation of macroautophagy
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016477biological_processcell migration
A0016533cellular_componentprotein kinase 5 complex
A0018105biological_processpeptidyl-serine phosphorylation
A0018107biological_processpeptidyl-threonine phosphorylation
A0019233biological_processsensory perception of pain
A0021537biological_processtelencephalon development
A0021549biological_processcerebellum development
A0021695biological_processcerebellar cortex development
A0021697biological_processcerebellar cortex formation
A0021766biological_processhippocampus development
A0021819biological_processlayer formation in cerebral cortex
A0021954biological_processcentral nervous system neuron development
A0021987biological_processcerebral cortex development
A0022038biological_processcorpus callosum development
A0030027cellular_componentlamellipodium
A0030054cellular_componentcell junction
A0030175cellular_componentfilopodium
A0030182biological_processneuron differentiation
A0030334biological_processregulation of cell migration
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030426cellular_componentgrowth cone
A0030517biological_processnegative regulation of axon extension
A0030549molecular_functionacetylcholine receptor activator activity
A0030900biological_processforebrain development
A0031175biological_processneuron projection development
A0031397biological_processnegative regulation of protein ubiquitination
A0031594cellular_componentneuromuscular junction
A0031914biological_processnegative regulation of synaptic plasticity
A0032801biological_processreceptor catabolic process
A0035249biological_processsynaptic transmission, glutamatergic
A0035418biological_processprotein localization to synapse
A0042220biological_processresponse to cocaine
A0042981biological_processregulation of apoptotic process
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043113biological_processreceptor clustering
A0043125molecular_functionErbB-3 class receptor binding
A0043204cellular_componentperikaryon
A0043525biological_processpositive regulation of neuron apoptotic process
A0045202cellular_componentsynapse
A0045786biological_processnegative regulation of cell cycle
A0045861biological_processnegative regulation of proteolysis
A0045892biological_processnegative regulation of DNA-templated transcription
A0045956biological_processpositive regulation of calcium ion-dependent exocytosis
A0046826biological_processnegative regulation of protein export from nucleus
A0048148biological_processbehavioral response to cocaine
A0048156molecular_functiontau protein binding
A0048167biological_processregulation of synaptic plasticity
A0048488biological_processsynaptic vesicle endocytosis
A0048489biological_processsynaptic vesicle transport
A0048511biological_processrhythmic process
A0048675biological_processaxon extension
A0048709biological_processoligodendrocyte differentiation
A0048813biological_processdendrite morphogenesis
A0050321molecular_functiontau-protein kinase activity
A0051301biological_processcell division
A0051402biological_processneuron apoptotic process
A0051649biological_processestablishment of localization in cell
A0051726biological_processregulation of cell cycle
A0051879molecular_functionHsp90 protein binding
A0051966biological_processregulation of synaptic transmission, glutamatergic
A0060078biological_processregulation of postsynaptic membrane potential
A0060079biological_processexcitatory postsynaptic potential
A0061001biological_processregulation of dendritic spine morphogenesis
A0070509biological_processcalcium ion import
A0090314biological_processpositive regulation of protein targeting to membrane
A0098793cellular_componentpresynapse
A0106310molecular_functionprotein serine kinase activity
A1903076biological_processregulation of protein localization to plasma membrane
A1903421biological_processregulation of synaptic vesicle recycling
A1904646biological_processcellular response to amyloid-beta
A2000251biological_processobsolete positive regulation of actin cytoskeleton reorganization
B0000226biological_processmicrotubule cytoskeleton organization
B0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
B0001764biological_processneuron migration
B0001963biological_processsynaptic transmission, dopaminergic
B0002039molecular_functionp53 binding
B0004672molecular_functionprotein kinase activity
B0004674molecular_functionprotein serine/threonine kinase activity
B0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
B0005176molecular_functionErbB-2 class receptor binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005874cellular_componentmicrotubule
B0005886cellular_componentplasma membrane
B0006468biological_processprotein phosphorylation
B0006886biological_processintracellular protein transport
B0006915biological_processapoptotic process
B0007160biological_processcell-matrix adhesion
B0007268biological_processchemical synaptic transmission
B0007399biological_processnervous system development
B0007409biological_processaxonogenesis
B0007416biological_processsynapse assembly
B0007519biological_processskeletal muscle tissue development
B0008017molecular_functionmicrotubule binding
B0008045biological_processmotor neuron axon guidance
B0008306biological_processassociative learning
B0008542biological_processvisual learning
B0014044biological_processSchwann cell development
B0014069cellular_componentpostsynaptic density
B0016020cellular_componentmembrane
B0016079biological_processsynaptic vesicle exocytosis
B0016241biological_processregulation of macroautophagy
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016477biological_processcell migration
B0016533cellular_componentprotein kinase 5 complex
B0018105biological_processpeptidyl-serine phosphorylation
B0018107biological_processpeptidyl-threonine phosphorylation
B0019233biological_processsensory perception of pain
B0021537biological_processtelencephalon development
B0021549biological_processcerebellum development
B0021695biological_processcerebellar cortex development
B0021697biological_processcerebellar cortex formation
B0021766biological_processhippocampus development
B0021819biological_processlayer formation in cerebral cortex
B0021954biological_processcentral nervous system neuron development
B0021987biological_processcerebral cortex development
B0022038biological_processcorpus callosum development
B0030027cellular_componentlamellipodium
B0030054cellular_componentcell junction
B0030175cellular_componentfilopodium
B0030182biological_processneuron differentiation
B0030334biological_processregulation of cell migration
B0030424cellular_componentaxon
B0030425cellular_componentdendrite
B0030426cellular_componentgrowth cone
B0030517biological_processnegative regulation of axon extension
B0030549molecular_functionacetylcholine receptor activator activity
B0030900biological_processforebrain development
B0031175biological_processneuron projection development
B0031397biological_processnegative regulation of protein ubiquitination
B0031594cellular_componentneuromuscular junction
B0031914biological_processnegative regulation of synaptic plasticity
B0032801biological_processreceptor catabolic process
B0035249biological_processsynaptic transmission, glutamatergic
B0035418biological_processprotein localization to synapse
B0042220biological_processresponse to cocaine
B0042981biological_processregulation of apoptotic process
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043113biological_processreceptor clustering
B0043125molecular_functionErbB-3 class receptor binding
B0043204cellular_componentperikaryon
B0043525biological_processpositive regulation of neuron apoptotic process
B0045202cellular_componentsynapse
B0045786biological_processnegative regulation of cell cycle
B0045861biological_processnegative regulation of proteolysis
B0045892biological_processnegative regulation of DNA-templated transcription
B0045956biological_processpositive regulation of calcium ion-dependent exocytosis
B0046826biological_processnegative regulation of protein export from nucleus
B0048148biological_processbehavioral response to cocaine
B0048156molecular_functiontau protein binding
B0048167biological_processregulation of synaptic plasticity
B0048488biological_processsynaptic vesicle endocytosis
B0048489biological_processsynaptic vesicle transport
B0048511biological_processrhythmic process
B0048675biological_processaxon extension
B0048709biological_processoligodendrocyte differentiation
B0048813biological_processdendrite morphogenesis
B0050321molecular_functiontau-protein kinase activity
B0051301biological_processcell division
B0051402biological_processneuron apoptotic process
B0051649biological_processestablishment of localization in cell
B0051726biological_processregulation of cell cycle
B0051879molecular_functionHsp90 protein binding
B0051966biological_processregulation of synaptic transmission, glutamatergic
B0060078biological_processregulation of postsynaptic membrane potential
B0060079biological_processexcitatory postsynaptic potential
B0061001biological_processregulation of dendritic spine morphogenesis
B0070509biological_processcalcium ion import
B0090314biological_processpositive regulation of protein targeting to membrane
B0098793cellular_componentpresynapse
B0106310molecular_functionprotein serine kinase activity
B1903076biological_processregulation of protein localization to plasma membrane
B1903421biological_processregulation of synaptic vesicle recycling
B1904646biological_processcellular response to amyloid-beta
B2000251biological_processobsolete positive regulation of actin cytoskeleton reorganization
D0016533cellular_componentprotein kinase 5 complex
D0061575molecular_functioncyclin-dependent protein serine/threonine kinase activator activity
E0016533cellular_componentprotein kinase 5 complex
E0061575molecular_functioncyclin-dependent protein serine/threonine kinase activator activity
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 3O0 B 293
ChainResidue
BVAL18
BASN144
BHOH311
BALA31
BLYS33
BVAL64
BGLU81
BCYS83
BASP84
BGLN85
BLEU133

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGTVFkAknrethei..........VALK
ChainResidueDetails
AILE10-LYS33

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpqNLLI
ChainResidueDetails
AVAL122-ILE134

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027
ChainResidueDetails
AASP126
BASP126

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE10
ALYS33
BILE10
BLYS33

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by ABL1, EPHA4 and FYN => ECO:0000269|PubMed:15689152, ECO:0000269|PubMed:17143272
ChainResidueDetails
ATYR15
BTYR15

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ATHR17
BTHR17

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS56
BLYS56

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195
ChainResidueDetails
ASER72
BSER72

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10500146
ChainResidueDetails
ASER159
BSER159

222415

PDB entries from 2024-07-10

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